Curated Information
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Home > Curated Information Page > PubMed Id: 10617468
Brondello JM, Pouysségur J, McKenzie FR (1999) Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. Science 286, 2514-7 10617468
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S359-p - DUSP1 (human)
Modsite: SALSYLQsPITTsPS SwissProt Entrez-Gene
Orthologous residues
DUSP1 (human): S359‑p, DUSP1 (mouse): S359‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), Dede (fibroblast)
Cellular systems studied:  cell lines
Species studied:  hamster, human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK1 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ERK1 (human) modification site within consensus motif
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
serum increase
estradiol increase
PD98059 estradiol inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  protein stabilization

S364-p - DUSP1 (human)
Modsite: LQsPITTsPSC____ SwissProt Entrez-Gene
Orthologous residues
DUSP1 (human): S364‑p, DUSP1 (mouse): S364‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), Dede (fibroblast)
Cellular systems studied:  cell lines
Species studied:  hamster, human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK1 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ERK1 (human) modification site within consensus motif
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
serum increase
estradiol increase
PD98059 estradiol inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  protein stabilization