Curated Information
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Home > Curated Information Page > PubMed Id: 17045208
Guo Z, et al. (2006) Regulation of androgen receptor activity by tyrosine phosphorylation. Cancer Cell 10, 309-19 17045208
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y225-p - AR (human)
Modsite: PtsSKDNyLGGTSTI SwissProt Entrez-Gene
Orthologous residues
AR (human): Y225‑p, AR iso3 (human): Y225‑p, AR (mouse): Y218‑p, AR (rat): Y221‑p

Y269-p - AR (human)
Modsite: QLRGDCMyAPLLGVP SwissProt Entrez-Gene
Orthologous residues
AR (human): Y269‑p, AR iso3 (human): Y269‑p, AR (mouse): Y262‑p, AR (rat): Y265‑p

Y309-p - AR (human)
Modsite: STEDTAEysPFKGGY SwissProt Entrez-Gene
Orthologous residues
AR (human): Y309‑p, AR iso3 (human): Y309‑p, AR (mouse): Y302‑p, AR (rat): Y305‑p

Y348-p - AR (human)
Modsite: LPSTLSLyKSGALDE SwissProt Entrez-Gene
Orthologous residues
AR (human): Y348‑p, AR iso3 (human): Y348‑p, AR (mouse): Y341‑p, AR (rat): Y344‑p

Y359-p - AR (human)
Modsite: ALDEAAAyQSRDyyN SwissProt Entrez-Gene
Orthologous residues
AR (human): Y359‑p, AR iso3 (human): Y359‑p, AR (mouse): Y352‑p, AR (rat): Y355‑p

Y364-p - AR (human)
Modsite: AAyQSRDyyNFPLAL SwissProt Entrez-Gene
Orthologous residues
AR (human): Y364‑p, AR iso3 (human): Y364‑p, AR (mouse): Y357‑p, AR (rat): Y360‑p

Y365-p - AR (human)
Modsite: AyQSRDyyNFPLALA SwissProt Entrez-Gene
Orthologous residues
AR (human): Y365‑p, AR iso3 (human): Y365‑p, AR (mouse): Y358‑p, AR (rat): Y361‑p

Y395-p - AR (human)
Modsite: kLENPLDyGSAWAAA SwissProt Entrez-Gene
Orthologous residues
AR (human): Y395‑p, AR iso3 (human): Y395‑p, AR (mouse): Y388‑p, AR (rat): Y391‑p

Y535-p - AR (human)
Modsite: MDSYSGPyGDMRLET SwissProt Entrez-Gene
Orthologous residues
AR (human): Y535‑p, AR iso3 (human): Y535‑p, AR (mouse): Y514‑p, AR (rat): Y517‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
androstanolone increase
siRNA Src (human) decrease
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  cell cycle regulation, transcription, altered
Comments:  Location affected under androgen-depleted conditions
Associated Diseases
Diseases Alterations Comments
prostate cancer increased phosphorylated Src and AR higher in hormone-refractory prostate cancers than hormone-sensitive ones.

Y552-p - AR (human)
Modsite: DHVLPIDyYFPPQKT SwissProt Entrez-Gene
Orthologous residues
AR (human): Y552‑p, AR iso3 (human): Y552‑p, AR (mouse): Y531‑p, AR (rat): Y534‑p

Y916-p - AR (human)
Modsite: SGKVKPIyFHTQ___ SwissProt Entrez-Gene
Orthologous residues
AR (human): Y916‑p, AR iso3 (human): , AR (mouse): Y895‑p, AR (rat): Y898‑p

T202-p - ERK1 (human)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): T202‑p, ERK1 iso2 (human): T202‑p, ERK1 iso3 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA Src (human) no change compared to control

Y204-p - ERK1 (human)
Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): Y204‑p, ERK1 iso2 (human): Y204‑p, ERK1 iso3 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA Src (human) no change compared to control

T185-p - ERK2 (human)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p, ERK2 (cow): T185‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA Src (human) no change compared to control

Y187-p - ERK2 (human)
Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p, ERK2 (cow): Y187‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA Src (human) no change compared to control

Y419-p - Src (human)
Modsite: RLIEDNEytARQGAk SwissProt Entrez-Gene
Orthologous residues
Src (human): Y419‑p, Src iso2 (human): Y425‑p, Src (mouse): Y418‑p, Src iso1 (mouse): Y424‑p, Src (rat): Y419‑p, Src (chicken): Y416‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
Associated Diseases
Diseases Alterations Comments
prostate cancer increased phosphorylated Src and AR higher in hormone-refractory prostate cancers than hormone-sensitive ones.

Y530-p - Src (human)
Modsite: FTstEPQyQPGENL_ SwissProt Entrez-Gene
Orthologous residues
Src (human): Y530‑p, Src iso2 (human): Y536‑p, Src (mouse): Y529‑p, Src iso1 (mouse): Y535‑p, Src (rat): Y530‑p, Src (chicken): Y527‑p