Curated Information
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Home > Curated Information Page > PubMed Id: 9528788
Potter LR, Hunter T (1998) Phosphorylation of the kinase homology domain is essential for activation of the A-type natriuretic peptide receptor. Mol Cell Biol 18, 2164-72 9528788
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S529-p - ANPA (human)
Modsite: RHLRSAGsRLtLsGR SwissProt Entrez-Gene
Orthologous residues
ANPA (human): S529‑p, ANPA (mouse): S525‑p, ANPA (rat): S525‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, phosphoamino acid analysis, phosphopeptide mapping
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Downstream Regulation
Effect of modification (function):  activity, induced

T532-p - ANPA (human)
Modsite: RSAGsRLtLsGRGsN SwissProt Entrez-Gene
Orthologous residues
ANPA (human): T532‑p, ANPA (mouse): T528‑p, ANPA (rat): T528‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, phosphoamino acid analysis, phosphopeptide mapping
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  activity, induced

S534-p - ANPA (human)
Modsite: AGsRLtLsGRGsNYG SwissProt Entrez-Gene
Orthologous residues
ANPA (human): S534‑p, ANPA (mouse): S530‑p, ANPA (rat): S530‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, phosphoamino acid analysis, phosphopeptide mapping
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  activity, induced

S538-p - ANPA (human)
Modsite: LtLsGRGsNYGsLLt SwissProt Entrez-Gene
Orthologous residues
ANPA (human): S538‑p, ANPA (mouse): S534‑p, ANPA (rat): S534‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, phosphoamino acid analysis, phosphopeptide mapping
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  activity, induced

S542-p - ANPA (human)
Modsite: GRGsNYGsLLtTEGQ SwissProt Entrez-Gene
Orthologous residues
ANPA (human): S542‑p, ANPA (mouse): S538‑p, ANPA (rat): S538‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, phosphoamino acid analysis, phosphopeptide mapping
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  activity, induced

T545-p - ANPA (human)
Modsite: sNYGsLLtTEGQFQV SwissProt Entrez-Gene
Orthologous residues
ANPA (human): T545‑p, ANPA (mouse): T541‑p, ANPA (rat): T541‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, phosphoamino acid analysis, phosphopeptide mapping
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  activity, induced