Shin EY, et al. (2006) betaPak-interacting exchange factor-mediated Rac1 activation requires smgGDS guanine nucleotide exchange factor in basic fibroblast growth factor-induced neurite outgrowth. J Biol Chem 281, 35954-64 16954223

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S703-p - ARHGEF7 (human) ▲

Modsite: EEFAsRkstAALEED SwissProt Entrez-Gene Orthologous residues ARHGEF7 (human): S703‑p, ARHGEF7 iso1 (human): S525‑p, ARHGEF7 iso5 (human): S610‑p, ARHGEF7 (mouse): S682‑p, ARHGEF7 iso2 (mouse): S682‑p, ARHGEF7 iso3 (mouse): S607‑p, ARHGEF7 (rat): S525‑p, ARHGEF7 (cow): S653‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  adrenal cancer, pheochromocytoma Relevant cell lines - cell types - tissues:  PC-12 (chromaffin) Cellular systems studied:  cell lines Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes FGF2 increase Downstream Regulation Effect of modification (function):  activity, induced, molecular association, regulation Effect of modification (process):  cytoskeletal reorganization Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays RAP1GDS1 (human) Disrupts pull-down assay Comments:  activates ARHGEF7's exchange activity on Rac1

T704-p - ARHGEF7 (human) ▲

Modsite: EFAsRkstAALEEDA SwissProt Entrez-Gene Orthologous residues ARHGEF7 (human): T704‑p, ARHGEF7 iso1 (human): T526‑p, ARHGEF7 iso5 (human): T611‑p, ARHGEF7 (mouse): T683‑p, ARHGEF7 iso2 (mouse): T683‑p, ARHGEF7 iso3 (mouse): T608‑p, ARHGEF7 (rat): T526‑p, ARHGEF7 (cow): T654‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  adrenal cancer, pheochromocytoma Relevant cell lines - cell types - tissues:  PC-12 (chromaffin) Cellular systems studied:  cell lines Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes FGF2 increase Downstream Regulation Effect of modification (function):  activity, induced, molecular association, regulation Effect of modification (process):  cytoskeletal reorganization Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays RAP1GDS1 (human) Disrupts pull-down assay Comments:  activates ARHGEF7's exchange activity on Rac1