Harish S, Ashok MS, Khanam T, Rangarajan PN (2000) Serine 27, a human retinoid X receptor alpha residue, phosphorylated by protein kinase A is essential for cyclicAMP-mediated downregulation of RXRalpha function. Biochem Biophys Res Commun 279, 853-7 11162439

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S27-p - RXRA (human) ▲

Modsite: tsPTGRGsMAAPsLH SwissProt Entrez-Gene Orthologous residues RXRA (human): S27‑p, RXRA (mouse): S28‑p, RXRA (rat): S28‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  COS (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKACA (human) modification site within consensus motif, pharmacological activator of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes cAMP_analog increase Downstream Regulation Effect of modification (function):  activity, inhibited Effect of modification (process):  transcription, altered