Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.0.1
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 11162439
Harish S, Ashok MS, Khanam T, Rangarajan PN (2000) Serine 27, a human retinoid X receptor alpha residue, phosphorylated by protein kinase A is essential for cyclicAMP-mediated downregulation of RXRalpha function. Biochem Biophys Res Commun 279, 853-7 11162439
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Click on the protein name to open the protein page, and on the RSD number to open the site page.

S27-p - RXRA (human)
Modsite: tsPTGRGsMAAPsLH SwissProt Entrez-Gene
Orthologous residues
RXRA (human): S27‑p, RXRA (mouse): S28‑p, RXRA (rat): S28‑p
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey
Enzymes shown to modify site in vitro
Type Enzyme
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (human) modification site within consensus motif, pharmacological activator of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
cAMP_analog increase
Downstream Regulation
Effect of modification (function):  activity, inhibited
Effect of modification (process):  transcription, altered