Lin D, et al. (2002) Protein kinase C (PKC)-induced phosphorylation of ROMK1 is essential for the surface expression of ROMK1 channels. J Biol Chem 277, 44278-84 12221079

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S4-p - ROMK (human) ▲

Modsite: ____MNAsSRNVFDT SwissProt Entrez-Gene Orthologous residues ROMK (human): S4‑p, ROMK (mouse): ‑, ROMK (rat): S4‑p, ROMK iso2 (rat): ‑ Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial), COS (fibroblast), oocyte Cellular systems studied:  cell lines, primary cells Species studied:  frog, green monkey, human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCA (human) Downstream Regulation Effect of modification (function):  activity, induced, intracellular localization

S183-p - ROMK (human) ▲

Modsite: GAILAKIsRPKKRAK SwissProt Entrez-Gene Orthologous residues ROMK (human): S183‑p, ROMK (mouse): S164‑p, ROMK (rat): S183‑p, ROMK iso2 (rat): S164‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial), COS (fibroblast), oocyte Cellular systems studied:  cell lines, primary cells Species studied:  frog, green monkey, human Downstream Regulation Effect of modification (function):  activity, induced, intracellular localization

S201-p - ROMK (human) ▲

Modsite: FSKNAVIskRGGKLC SwissProt Entrez-Gene Orthologous residues ROMK (human): S201‑p, ROMK (mouse): S182‑p, ROMK (rat): S201‑p, ROMK iso2 (rat): S182‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial), COS (fibroblast), oocyte Cellular systems studied:  cell lines, primary cells Species studied:  frog, green monkey, human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCA (human) Downstream Regulation Effect of modification (function):  activity, induced, intracellular localization