Curated Information
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Home > Curated Information Page > PubMed Id: 11086991
Mendez A, et al. (2000) Rapid and reproducible deactivation of rhodopsin requires multiple phosphorylation sites. Neuron 28, 153-64 11086991
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S334-p - Rhodopsin (mouse)
Modsite: PLGDDDAsATAsKtE SwissProt Entrez-Gene
Orthologous residues
Rhodopsin (human): S334‑p, Rhodopsin (mouse): S334‑p, Rhodopsin (rat): S334‑p, Rhodopsin (cow): S334‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  retina
Cellular systems studied:  primary cells, tissue
Species studied:  mouse
Comments:  mutations in transgenic mice
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
light increase
Downstream Regulation
Effect of modification (function):  receptor inactivation, altered
Comments:  Mutant rhodopsins had prolonged rate of recovery with increasing number of phosphorylation sites.

S338-p - Rhodopsin (mouse)
Modsite: DDAsATAsKtEtsQV SwissProt Entrez-Gene
Orthologous residues
Rhodopsin (human): S338‑p, Rhodopsin (mouse): S338‑p, Rhodopsin (rat): S338‑p, Rhodopsin (cow): S338‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  retina
Cellular systems studied:  primary cells, tissue
Species studied:  mouse
Comments:  mutations in transgenic mice
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
light increase
Downstream Regulation
Effect of modification (function):  receptor inactivation, altered
Comments:  Mutant rhodopsins had prolonged rate of recovery with increasing number of phosphorylation sites.