Curated Information
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Home > Curated Information Page > PubMed Id: 30185623
Deguire SM, et al. (2018) N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting. J Biol Chem 30185623
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T3-p - Huntingtin (human)
Modsite: _____MAtLEkLMkA SwissProt Entrez-Gene
Orthologous residues
Huntingtin (human): T3‑p, Huntingtin (mouse): T3‑p, Huntingtin (rat):
Downstream Regulation
Effect of modification (function):  protein conformation

S13-p - Huntingtin (human)
Modsite: kLMkAFEsLksFQQQ SwissProt Entrez-Gene
Orthologous residues
Huntingtin (human): S13‑p, Huntingtin (mouse): S13‑p, Huntingtin (rat): S6‑p
Characterization
Methods used to characterize site in vivo immunoassay, mutation of modification site
Relevant cell lines - cell types - tissues:  'neuron, striatal'-brain
Cellular systems studied:  primary cultured cells
Species studied:  rat
Downstream Regulation
Effect of modification (function):  intracellular localization, molecular association, regulation, protein conformation, receptor internalization, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Huntingtin (human) Disrupts
Comments:  inhibits aggregation; disrupts conformation of the protein induced by phosphorylation of T3 residue

S16-p - Huntingtin (human)
Modsite: kAFEsLksFQQQQQQ SwissProt Entrez-Gene
Orthologous residues
Huntingtin (human): S16‑p, Huntingtin (mouse): S16‑p, Huntingtin (rat): S9‑p
Characterization
Methods used to characterize site in vivo immunoassay, mutation of modification site
Relevant cell lines - cell types - tissues:  'neuron, striatal'-brain
Cellular systems studied:  primary cultured cells
Species studied:  rat
Downstream Regulation
Effect of modification (function):  intracellular localization, molecular association, regulation, protein conformation, receptor internalization, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Huntingtin (human) Disrupts
Comments:  inhibits aggregation; disrupts conformation of the protein induced by phosphorylation of T3 residue