Kato M, et al. (2002) Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine. Cancer Res 62, 2414-22 11956105

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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Y905-p - Ret (human) ▲

Modsite: DVyEEDsyVKRsQGR SwissProt Entrez-Gene Orthologous residues Ret (human): Y905‑p, Ret iso2 (human): Y905‑p, Ret iso3 (human): Y429‑p, Ret (mouse): Y906‑p, Ret iso2 (mouse): Y906‑p, Ret iso4 (mouse): ‑, Ret (rat): Y906‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  3T3 (fibroblast), SYF (fibroblast) Cellular systems studied:  cell lines Species studied:  mouse Enzymes shown to modify site in vitro:  Type Enzyme KINASE Src (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE Src iso1 (mouse) genetic knockout/knockin of upstream enzyme, phospho-antibody, co-immunoprecipitation, genetic transfer of wild-type enzyme Downstream Regulation Effect of modification (function):  enzymatic activity, induced Effect of modification (process):  cell growth, altered

Y928-p - Ret (human) ▲

Modsite: ESLFDHIyTTQSDVW SwissProt Entrez-Gene Orthologous residues Ret (human): Y928‑p, Ret iso2 (human): Y928‑p, Ret iso3 (human): Y452‑p, Ret (mouse): Y929‑p, Ret iso2 (mouse): Y929‑p, Ret iso4 (mouse): ‑, Ret (rat): Y929‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  3T3 (fibroblast) Cellular systems studied:  cell lines Species studied:  mouse Downstream Regulation Effect of modification (function):  enzymatic activity, induced

Y952-p - Ret (human) ▲

Modsite: VTLGGNPyPGIPPER SwissProt Entrez-Gene Orthologous residues Ret (human): Y952‑p, Ret iso2 (human): Y952‑p, Ret iso3 (human): Y476‑p, Ret (mouse): Y953‑p, Ret iso2 (mouse): Y953‑p, Ret iso4 (mouse): ‑, Ret (rat): Y953‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  3T3 (fibroblast) Cellular systems studied:  cell lines Species studied:  mouse Downstream Regulation Effect of modification (function):  enzymatic activity, induced

Y981-p - Ret (human) ▲

Modsite: DNCSEEMyRLMLQCW SwissProt Entrez-Gene Orthologous residues Ret (human): Y981‑p, Ret iso2 (human): Y981‑p, Ret iso3 (human): Y505‑p, Ret (mouse): Y982‑p, Ret iso2 (mouse): Y982‑p, Ret iso4 (mouse): ‑, Ret (rat): Y982‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  3T3 (fibroblast) Cellular systems studied:  cell lines Species studied:  mouse Downstream Regulation Effect of modification (function):  enzymatic activity, induced

Y1062-p - Ret (human) ▲

Modsite: TWIENkLyGMsDPNW SwissProt Entrez-Gene Orthologous residues Ret (human): Y1062‑p, Ret iso2 (human): Y1062‑p, Ret iso3 (human): Y586‑p, Ret (mouse): Y1063‑p, Ret iso2 (mouse): Y1063‑p, Ret iso4 (mouse): ‑, Ret (rat): Y1063‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  3T3 (fibroblast) Cellular systems studied:  cell lines Species studied:  mouse Downstream Regulation Effect of modification (process):  cell growth, altered