Blanquart C, et al. (2004) The protein kinase C signaling pathway regulates a molecular switch between transactivation and transrepression activity of the peroxisome proliferator-activated receptor alpha. Mol Endocrinol 18, 1906-18 15131257

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S179-p - PPAR-alpha (human) ▲

Modsite: RFGRMPRsEKAKLkA SwissProt Entrez-Gene Orthologous residues PPAR‑alpha (human): S179‑p, PPAR‑alpha (mouse): S179‑p, PPAR‑alpha (rat): S179‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  liver cancer Relevant cell lines - cell types - tissues:  Huh7 (hepatic) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCB iso2 (human) KINASE PKCA (human) Downstream Regulation Effect of modification (process):  transcription, altered

S230-p - PPAR-alpha (human) ▲

Modsite: VKARVILsGKASNNP SwissProt Entrez-Gene Orthologous residues PPAR‑alpha (human): S230‑p, PPAR‑alpha (mouse): A230‑p, PPAR‑alpha (rat): A230‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  liver cancer Relevant cell lines - cell types - tissues:  Huh7 (hepatic) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCB iso2 (human) KINASE PKCA (human) Downstream Regulation Effect of modification (process):  transcription, altered