Curated Information
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Home > Curated Information Page > PubMed Id: 11085936
Parekh DB, et al. (2000) Beta1-integrin and PTEN control the phosphorylation of protein kinase C. Biochem J 352 Pt 2, 425-33 11085936
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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T566-p - PKCE (human)
Modsite: LNGVTTTtFCGTPDy SwissProt Entrez-Gene
Orthologous residues
PKCE (human): T566‑p, PKCE (mouse): T566‑p, PKCE (rat): T566‑p
Characterization
Methods used to characterize site in vivo phosphoamino acid analysis, western blotting
Disease tissue studied:  bladder cancer
Relevant cell lines - cell types - tissues:  293 (epithelial), UMUC3 (bladder cell)
Cellular systems studied:  cell lines
Species studied:  human

S729-p - PKCE (human)
Modsite: QEEFKGFsYFGEDLM SwissProt Entrez-Gene
Orthologous residues
PKCE (human): S729‑p, PKCE (mouse): S729‑p, PKCE (rat): S729‑p
Characterization
Methods used to characterize site in vivo phosphoamino acid analysis, western blotting
Disease tissue studied:  bladder cancer
Relevant cell lines - cell types - tissues:  293 (epithelial), UMUC3 (bladder cell)
Cellular systems studied:  cell lines
Species studied:  human

T505-p - PKCD (mouse)
Modsite: FGEGRAstFCGtPDY SwissProt Entrez-Gene
Orthologous residues
PKCD (human): T507‑p, PKCD iso2 (human): T538‑p, PKCD (mouse): T505‑p, PKCD iso2 (mouse): T531‑p, PKCD (rat): T505‑p
Characterization
Methods used to characterize site in vivo phosphoamino acid analysis, western blotting
Disease tissue studied:  bladder cancer
Relevant cell lines - cell types - tissues:  293 (epithelial), UMUC3 (bladder cell)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
cell_adhesion increase
LY294002 cell_adhesion no effect upon treatment-induced increase
serum increase cells in suspension
LY294002 serum inhibit treatment-induced increase cells in suspension

S662-p - PKCD (mouse)
Modsite: QEAFHGFsFVNPKFE SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S664‑p, PKCD iso2 (human): S695‑p, PKCD (mouse): S662‑p, PKCD iso2 (mouse): S688‑p, PKCD (rat): S662‑p
Characterization
Methods used to characterize site in vivo phosphoamino acid analysis, western blotting
Disease tissue studied:  bladder cancer
Relevant cell lines - cell types - tissues:  293 (epithelial), UMUC3 (bladder cell)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
cell_adhesion increase
LY294002 cell_adhesion no effect upon treatment-induced increase
serum increase cells in suspension
LY294002 serum inhibit treatment-induced increase cells in suspension