Miggin SM, Kinsella BT (2002) Investigation of the mechanisms of G protein: effector coupling by the human and mouse prostacyclin receptors. Identification of critical species-dependent differences. J Biol Chem 277, 27053-64 12016224

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S328-p - PTGIR (human) ▲

Modsite: TPLSQLAsGRRDPRA SwissProt Entrez-Gene Orthologous residues PTGIR (human): S328‑p, PTGIR (mouse): S355‑p, PTGIR (rat): S356‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKCA (human) pharmacological inhibitor of upstream enzyme, modification site within consensus motif, pharmacological activator of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes cicaprost increase H-89 cicaprost no effect upon treatment-induced increase GF109203X cicaprost inhibit treatment-induced increase