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Home > Curated Information Page > PubMed Id: 12056906
Fontayne A, Dang PM, Gougerot-Pocidalo MA, El-Benna J (2002) Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation. Biochemistry 41, 7743-50 12056906
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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S303-p - p47phox (human)
Modsite: RGAPPRRssIRNAHs SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S303‑p, p47phox (mouse): S304‑p, p47phox (rat): S304‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (human)
KINASE PKCB iso2 (human)
KINASE PKCD (human)
Downstream Regulation
Effect of modification (function):  activity, induced, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CYBA (human) Induces far-Western
Comments:  NADPH oxidase activation

S304-p - p47phox (human)
Modsite: GAPPRRssIRNAHsI SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S304‑p, p47phox (mouse): T305‑p, p47phox (rat): T305‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCB iso2 (human)
KINASE PKCD (human)
KINASE PKCA (human)
Downstream Regulation
Effect of modification (function):  activity, induced, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CYBA (human) Induces far-Western
Comments:  NADPH oxidase activation

S315-p - p47phox (human)
Modsite: AHsIHQRsRKRLsQD SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S315‑p, p47phox (mouse): S316‑p, p47phox (rat): S316‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (human)
KINASE PKCB iso2 (human)
KINASE PKCD (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CYBA (human) Induces far-Western

S320-p - p47phox (human)
Modsite: QRsRKRLsQDAYRRN SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S320‑p, p47phox (mouse): S321‑p, p47phox (rat): S321‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (human)
KINASE PKCD (human)
KINASE PKCB iso2 (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CYBA (human) Induces far-Western

S328-p - p47phox (human)
Modsite: QDAYRRNsVRFLQQR SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S328‑p, p47phox (mouse): S329‑p, p47phox (rat): S329‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCD (human)
KINASE PKCA (human)
KINASE PKCB iso2 (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CYBA (human) Induces far-Western

S359-p - p47phox (human)
Modsite: EERQtQRsKPQPAVP SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S359‑p, p47phox (mouse): V359‑p, p47phox (rat): A358‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (human)
KINASE PKCB iso2 (human)
KINASE PKCD (human)
Downstream Regulation
Effect of modification (function):  activity, induced, molecular association, regulation, phosphorylation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CYBA (human) Induces far-Western
Comments:  NADPH oxidase activation, promotes the phosphorylation of other p47phox PKC sites

S370-p - p47phox (human)
Modsite: PAVPPRPsADLILNR SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S370‑p, p47phox (mouse): S370‑p, p47phox (rat): S369‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCD (human)
KINASE PKCA (human)
KINASE PKCB iso2 (human)
Downstream Regulation
Effect of modification (function):  activity, induced, molecular association, regulation, phosphorylation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CYBA (human) Induces far-Western
Comments:  NADPH oxidase activation, promotes the phosphorylation of other p47phox PKC sites

S379-p - p47phox (human)
Modsite: DLILNRCsEstKRKL SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S379‑p, p47phox (mouse): T379‑p, p47phox (rat): T378‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCD (human)
KINASE PKCB iso2 (human)
KINASE PKCA (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CYBA (human) Induces far-Western