Curated Information
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Home > Curated Information Page > PubMed Id: 11063873
Curtis DJ, et al. (2000) Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest. Exp Hematol 28, 1250-9 11063873
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y260-p - SKAP2 (mouse)
Modsite: QPIDDEIyEELPEEE SwissProt Entrez-Gene
Orthologous residues
SKAP2 (human): Y261‑p, SKAP2 (mouse): Y260‑p, SKAP2 (rat): Y260‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  3T3 (fibroblast), bone marrow, COS (fibroblast), FDCP-1 (myeloid)
Cellular systems studied:  cell lines, primary cells
Species studied:  green monkey, mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Fyn (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Fyn (human) phospho-motif antibody, transfection of wild-type enzyme, co-immunoprecipitation, modification site within consensus motif
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell growth, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
LYN (human) Induces co-immunoprecipitation
Hck (human) Induces co-immunoprecipitation
Fyn (human) Induces co-immunoprecipitation