Curated Information
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Home > Curated Information Page > PubMed Id: 12123746
Wang HL, et al. (2002) Identification of two C-terminal amino acids, Ser(355) and Thr(357), required for short-term homologous desensitization of mu-opioid receptors. Biochem Pharmacol 64, 257-66 12123746
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S355-p - MOR-1 (rat)
Modsite: REFCIPTsstIEQQN SwissProt Entrez-Gene
Orthologous residues
MOR‑1 (human): S357‑p, MOR‑1 iso5 (human): S357‑p, MOR‑1 (mouse): S355‑p, MOR‑1 (rat): S355‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  phosphorylation, receptor desensitization, altered

T357-p - MOR-1 (rat)
Modsite: FCIPTsstIEQQNsT SwissProt Entrez-Gene
Orthologous residues
MOR‑1 (human): N359‑p, MOR‑1 iso5 (human): N359‑p, MOR‑1 (mouse): T357‑p, MOR‑1 (rat): T357‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  phosphorylation, receptor desensitization, altered