Kobayashi S, et al. (2004) The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1). FASEB J 18, 929-31 15001553

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Y1333-p - VEGFR1 (human) ▲

Modsite: DyNSVVLySTPPI__ SwissProt Entrez-Gene Orthologous residues VEGFR1 (human): Y1333‑p, VEGFR1 iso2 (human): ‑, VEGFR1 iso8 (human): Y356‑p, VEGFR1 (mouse): Y1328‑p, VEGFR1 (rat): Y1331‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  3T3 (fibroblast), SF9 Cellular systems studied:  cell lines Species studied:  insect, mouse Downstream Regulation Effect of modification (function):  molecular association, regulation, protein degradation, receptor internalization, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays CBL (human) SH2 Induces co-immunoprecipitation, microscopy-colocalization