Curated Information
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Home > Curated Information Page > PubMed Id: 11035084
Fong DC, et al. (2000) Mutational analysis reveals multiple distinct sites within Fc gamma receptor IIB that function in inhibitory signaling. J Immunol 165, 4453-62 11035084
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y235-p - FCGR2B (mouse)
Modsite: IILVsLVyLKKKQVP SwissProt Entrez-Gene
Orthologous residues
FCGR2B (human): Y246‑p, FCGR2B iso2 (human): Y246‑p, FCGR2B (mouse): Y235‑p, FCGR2B iso2 (mouse): Y235‑p, FCGR2B (rat): Y237‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  lymphoma, B cell lymphoma
Relevant cell lines - cell types - tissues:  A20 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
antibody increase

Y264-p - FCGR2B (mouse)
Modsite: LPEEVGEyRQPSGGS SwissProt Entrez-Gene
Orthologous residues
FCGR2B (human): , FCGR2B iso2 (human): , FCGR2B (mouse): Y264‑p, FCGR2B iso2 (mouse): , FCGR2B (rat):
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  lymphoma, B cell lymphoma
Relevant cell lines - cell types - tissues:  A20 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
antibody increase

Y290-p - FCGR2B (mouse)
Modsite: EPTSSSPyNPPDLEE SwissProt Entrez-Gene
Orthologous residues
FCGR2B (human): A273‑p, FCGR2B iso2 (human): A254‑p, FCGR2B (mouse): Y290‑p, FCGR2B iso2 (mouse): D243‑p, FCGR2B (rat):
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  lymphoma, B cell lymphoma
Relevant cell lines - cell types - tissues:  A20 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
antibody increase

Y309-p - FCGR2B (mouse)
Modsite: EAENTITySLLkHPE SwissProt Entrez-Gene
Orthologous residues
FCGR2B (human): Y292‑p, FCGR2B iso2 (human): Y273‑p, FCGR2B (mouse): Y309‑p, FCGR2B iso2 (mouse): Y262‑p, FCGR2B (rat): Y264‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  lymphoma, B cell lymphoma
Relevant cell lines - cell types - tissues:  A20 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
antibody increase
Downstream Regulation
Effect of modification (function):  activity, induced, phosphorylation
Comments:  regulates Ca(2+) influx, ERK activation, SHIP phosphorylation

Y326-p - FCGR2B (mouse)
Modsite: DEETEHDyQNHI___ SwissProt Entrez-Gene
Orthologous residues
FCGR2B (human): D306‑p, FCGR2B iso2 (human): D287‑p, FCGR2B (mouse): Y326‑p, FCGR2B iso2 (mouse): Y279‑p, FCGR2B (rat): Y281‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  lymphoma, B cell lymphoma
Relevant cell lines - cell types - tissues:  A20 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
antibody increase