Bek S, Kemler R (2002) Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability. J Cell Sci 115, 4743-53 12432063

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S29-p - CTNNB1 (human) ▲

Modsite: VsHWQQQsyLDsGIH SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S29‑p, CTNNB1 (mouse): S29‑p, CTNNB1 (rat): S29‑p, CTNNB1 (rabbit): S29‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE CK2A2 (human) Comments:  CK2-A2 and GSK3B can synergistically bind to CTNNB1. Downstream Regulation Effect of modification (function):  protein degradation Effect of modification (process):  cell motility, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays CTNNA1 (human) Induces cell motility, altered co-immunoprecipitation, in vitro

T102-p - CTNNB1 (human) ▲

Modsite: RAAMFPEtLDEGMQI SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): T102‑p, CTNNB1 (mouse): T102‑p, CTNNB1 (rat): T102‑p, CTNNB1 (rabbit): T102‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE CK2A2 (human) Comments:  CK2-A2 and GSK3B can synergistically bind to CTNNB1. Downstream Regulation Effect of modification (function):  protein degradation Effect of modification (process):  cell motility, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays CTNNA1 (human) Induces cell motility, altered co-immunoprecipitation, in vitro

T112-p - CTNNB1 (human) ▲

Modsite: EGMQIPstQFdAAHP SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): T112‑p, CTNNB1 (mouse): T112‑p, CTNNB1 (rat): T112‑p, CTNNB1 (rabbit): T112‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE CK2A2 (human) Comments:  CK2-A2 and GSK3B can synergistically bind to CTNNB1. Downstream Regulation Effect of modification (function):  protein degradation Effect of modification (process):  cell motility, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays CTNNA1 (human) Induces cell motility, altered co-immunoprecipitation, in vitro