Curated Information
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Home > Curated Information Page > PubMed Id: 12432063
Bek S, Kemler R (2002) Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability. J Cell Sci 115, 4743-53 12432063
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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S29-p - CTNNB1 (human)
Modsite: VsHWQQQsyLDsGIH SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): S29‑p, CTNNB1 (mouse): S29‑p, CTNNB1 (rat): S29‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A2 (human)
Comments:  CK2-A2 and GSK3B can synergistically bind to CTNNB1.
Downstream Regulation
Effect of modification (function):  protein degradation
Effect of modification (process):  cell motility, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CTNNA1 (human) Induces cell motility, altered co-immunoprecipitation, in vitro

T102-p - CTNNB1 (human)
Modsite: RAAMFPEtLDEGMQI SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): T102‑p, CTNNB1 (mouse): T102‑p, CTNNB1 (rat): T102‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A2 (human)
Comments:  CK2-A2 and GSK3B can synergistically bind to CTNNB1.
Downstream Regulation
Effect of modification (function):  protein degradation
Effect of modification (process):  cell motility, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CTNNA1 (human) Induces cell motility, altered co-immunoprecipitation, in vitro

T112-p - CTNNB1 (human)
Modsite: EGMQIPStQFdAAHP SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): T112‑p, CTNNB1 (mouse): T112‑p, CTNNB1 (rat): T112‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A2 (human)
Comments:  CK2-A2 and GSK3B can synergistically bind to CTNNB1.
Downstream Regulation
Effect of modification (function):  protein degradation
Effect of modification (process):  cell motility, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CTNNA1 (human) Induces cell motility, altered co-immunoprecipitation, in vitro