Curated Information
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Home > Curated Information Page > PubMed Id: 12611639
Maulik G, et al. (2002) Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer. J Cell Mol Med 6, 539-53 12611639
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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Y1003-p - Met (human)
Modsite: VsNEsVDyRAtFPED SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1003‑p, Met iso2 (human): Y1021‑p, Met (mouse): Y1001‑p, Met (rat): Y1004‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  lung cancer, small-cell lung cancer
Relevant cell lines - cell types - tissues:  NCI-H69 (pulmonary)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase

Y1230-p - Met (human)
Modsite: FGLARDMyDkEyysV SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1230‑p, Met iso2 (human): Y1248‑p, Met (mouse): Y1228‑p, Met (rat): Y1231‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  lung cancer, small-cell lung cancer
Relevant cell lines - cell types - tissues:  NCI-H69 (pulmonary)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase
HGF increase
geldanamycin no change compared to control
geldanamycin HGF inhibit treatment-induced increase

Y1234-p - Met (human)
Modsite: RDMyDkEyysVHNkt SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1234‑p, Met iso2 (human): Y1252‑p, Met (mouse): Y1232‑p, Met (rat): Y1235‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  lung cancer, small-cell lung cancer
Relevant cell lines - cell types - tissues:  NCI-H69 (pulmonary)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase
HGF increase
geldanamycin no change compared to control
geldanamycin HGF inhibit treatment-induced increase

Y1235-p - Met (human)
Modsite: DMyDkEyysVHNktG SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1235‑p, Met iso2 (human): Y1253‑p, Met (mouse): Y1233‑p, Met (rat): Y1236‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  lung cancer, small-cell lung cancer
Relevant cell lines - cell types - tissues:  NCI-H69 (pulmonary)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase
HGF increase
geldanamycin no change compared to control
geldanamycin HGF inhibit treatment-induced increase

Y1313-p - Met (human)
Modsite: EyCPDPLyEVMLkCW SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1313‑p, Met iso2 (human): Y1331‑p, Met (mouse): Y1311‑p, Met (rat): Y1314‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  lung cancer, small-cell lung cancer
Relevant cell lines - cell types - tissues:  NCI-H69 (pulmonary)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase