van Noort M, van de Wetering M, Clevers H (2002) Identification of two novel regulated serines in the N terminus of beta-catenin. Exp Cell Res 276, 264-72 12027456

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S23-p - CTNNB1 (human) ▲

Modsite: PDRkAAVsHWQQQsy SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S23‑p, CTNNB1 (mouse): S23‑p, CTNNB1 (rat): S23‑p, CTNNB1 (rabbit): S23‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  breast cancer Relevant cell lines - cell types - tissues:  COS (fibroblast), HEK293T (epithelial), SKBr3 (breast cell) Cellular systems studied:  cell lines Species studied:  green monkey, human Comments:  RKE3 cells Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes lithium decrease WNT1 (human) decrease Downstream Regulation Comments:  no change in transcription or transforming activities

S29-p - CTNNB1 (human) ▲

Modsite: VsHWQQQsyLDsGIH SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S29‑p, CTNNB1 (mouse): S29‑p, CTNNB1 (rat): S29‑p, CTNNB1 (rabbit): S29‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  breast cancer Relevant cell lines - cell types - tissues:  COS (fibroblast), HEK293T (epithelial), SKBr3 (breast cell) Cellular systems studied:  cell lines Species studied:  green monkey, human Comments:  RKE3 cells Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes lithium decrease WNT1 (human) decrease Downstream Regulation Comments:  no change in transcription or transforming activities

S33-p - CTNNB1 (human) ▲

Modsite: QQQsyLDsGIHsGAT SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S33‑p, CTNNB1 (mouse): S33‑p, CTNNB1 (rat): S33‑p, CTNNB1 (rabbit): S33‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  breast cancer Relevant cell lines - cell types - tissues:  COS (fibroblast), HEK293T (epithelial), SKBr3 (breast cell) Cellular systems studied:  cell lines Species studied:  green monkey, human Comments:  RKE3 cells Downstream Regulation Effect of modification (process):  cell growth, altered

S37-p - CTNNB1 (human) ▲

Modsite: yLDsGIHsGATtTAP SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S37‑p, CTNNB1 (mouse): S37‑p, CTNNB1 (rat): S37‑p, CTNNB1 (rabbit): S37‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  breast cancer Relevant cell lines - cell types - tissues:  COS (fibroblast), HEK293T (epithelial), SKBr3 (breast cell) Cellular systems studied:  cell lines Species studied:  green monkey, human Comments:  RKE3 cells Downstream Regulation Effect of modification (process):  cell growth, altered

S23-p - CTNNB1 (mouse) ▲
Modsite: PDRkAAVsHWQQQsY SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S23‑p, CTNNB1 (mouse): S23‑p, CTNNB1 (rat): S23‑p, CTNNB1 (rabbit): S23‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  embryo Cellular systems studied:  tissue Species studied:  mouse

S29-p - CTNNB1 (mouse) ▲
Modsite: VsHWQQQsYLDsGIH SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S29‑p, CTNNB1 (mouse): S29‑p, CTNNB1 (rat): S29‑p, CTNNB1 (rabbit): S29‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  embryo Cellular systems studied:  tissue Species studied:  mouse