Basak C, et al. (2005) NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages. J Biol Chem 280, 4279-88 15561713

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S376-p - CASP1 (human) ▲

Modsite: IFRKVRFsFEQPDGR SwissProt Entrez-Gene Orthologous residues CASP1 (human): S376‑p, CASP1 iso4 (human): S235‑p, CASP1 (mouse): S374‑p, CASP1 (rat): S374‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  THP1 (myeloid) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  enzymatic activity, induced

S9-p - GSK3B (human) ▲

Modsite: SGRPRttsFAEsCkP SwissProt Entrez-Gene Orthologous residues GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S9‑p Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes LPS increase wortmannin LPS inhibit treatment-induced increase

T180-p - P38A (human) ▲

Modsite: RHtDDEMtGyVAtRW SwissProt Entrez-Gene Orthologous residues P38A (human): T180‑p, P38A iso2 (human): T180‑p, P38A (mouse): T180‑p, P38A iso3 (mouse): T180‑p, P38A (rat): T180‑p, P38A (salmonid): T181‑p Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes LPS PAK1 (human) no change compared to control PAK1 WT LPS PAK1 (human) no change compared to control PAC1 KD LPS increase wortmannin LPS inhibit treatment-induced increase A-443654 LPS inhibit treatment-induced increase

Y182-p - P38A (human) ▲

Modsite: tDDEMtGyVAtRWYR SwissProt Entrez-Gene Orthologous residues P38A (human): Y182‑p, P38A iso2 (human): Y182‑p, P38A (mouse): Y182‑p, P38A iso3 (mouse): Y182‑p, P38A (rat): Y182‑p, P38A (salmonid): Y183‑p Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes LPS PAK1 (human) no change compared to control PAK1 WT LPS PAK1 (human) no change compared to control PAC1 KD LPS increase wortmannin LPS inhibit treatment-induced increase A-443654 LPS inhibit treatment-induced increase

S199-p - PAK1 (human) ▲

Modsite: PRPEHtKsVyTRsVI SwissProt Entrez-Gene Orthologous residues PAK1 (human): S199‑p, PAK1 (mouse): S199‑p, PAK1 (rat): S198‑p Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes LPS increase wortmannin LPS inhibit treatment-induced increase LPS increase A-443654 LPS inhibit treatment-induced increase wortmannin LPS inhibit treatment-induced increase LPS Akt1 (human) increase LPS increase wortmannin LPS Akt1 (human) inhibit treatment-induced increase LPS Akt1 (human) increase Akt1 WT LPS LPS Akt1 (human) Akt1 (human) no effect upon treatment-induced increase Akt1 DN LPS increase vector LPS LPS RAC1 (human) inhibit treatment-induced increase Rac 1 DN

S204-p - PAK1 (human) ▲

Modsite: tKsVyTRsVIEPLPV SwissProt Entrez-Gene Orthologous residues PAK1 (human): S204‑p, PAK1 (mouse): S204‑p, PAK1 (rat): S203‑p Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes LPS increase wortmannin LPS inhibit treatment-induced increase LPS Akt1 (human) increase LPS increase wortmannin LPS Akt1 (human) inhibit treatment-induced increase LPS Akt1 (human) increase Akt1 WT LPS LPS Akt1 (human) Akt1 (human) no effect upon treatment-induced increase Akt1 DN LPS increase vector LPS LPS RAC1 (human) inhibit treatment-induced increase Rac 1 DN