Curated Information
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Home > Curated Information Page > PubMed Id: 16902180
Zhai P, et al. (2006) An angiotensin II type 1 receptor mutant lacking epidermal growth factor receptor transactivation does not induce angiotensin II-mediated cardiac hypertrophy. Circ Res 99, 528-36 16902180
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y319-p - AT1 (mouse)
Modsite: YFLQLLKyIPPKAKS SwissProt Entrez-Gene
Orthologous residues
AT1 (human): Y319‑p, AT1 (mouse): Y319‑p, AT1 (rat): Y319‑p
Downstream Regulation
Effect of modification (function):  activity, induced
Comments:  Transgenic mice with cardiac-specific overexpression of Y319F mutant AT1 have reduced EGFR activation, and do not develop cardiac hypertrophy, fibrosis or apoptosis

Y1172-p - EGFR (mouse)
Modsite: MsLDNPDyQQDFFPk SwissProt Entrez-Gene
Orthologous residues
EGFR (human): Y1172‑p, EGFR iso2 (human): , EGFR iso5 (human): , EGFR (mouse): Y1172‑p, EGFR (rat): Y1171‑p, EGFR (pig): Y1171‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
AT1 (mouse) no change compared to control Transgenic mice with cardiac-specific overexpression of Y319F-mutant AT1 showed no difference in phosphorylation of this site compared to WT.
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

Y705-p - STAT3 (mouse)
Modsite: DPGsAAPyLktkFIC SwissProt Entrez-Gene
Orthologous residues
STAT3 (human): Y705‑p, STAT3 iso2 (human): Y704‑p, STAT3 iso3 (human): Y705‑p, STAT3 (mouse): Y705‑p, STAT3 iso2 (mouse): Y705‑p, STAT3 iso3 (mouse): Y704‑p, STAT3 (rat): Y705‑p, STAT3 (cow): Y705‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
AT1 (mouse) no change compared to control Transgenic mice with cardiac-specific overexpression of Y319F-mutant AT1 exhibited no difference in phosphorylation of this site from WT.

S727-p - STAT3 (mouse)
Modsite: NtIDLPMsPRTLDSL SwissProt Entrez-Gene
Orthologous residues
STAT3 (human): S727‑p, STAT3 iso2 (human): S726‑p, STAT3 iso3 (human): , STAT3 (mouse): S727‑p, STAT3 iso2 (mouse): , STAT3 iso3 (mouse): S726‑p, STAT3 (rat): S727‑p, STAT3 (cow): S727‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
AT1 (mouse) no change compared to control Transgenic mice with cardiac-specific overexpression of Y319F-mutant AT1 exhibited no difference in phosphorylation of this site from WT.