Launay N, et al. (2006) Cell signaling pathways to alphaB-crystallin following stresses of the cytoskeleton. Exp Cell Res 312, 3570-84 16979163

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S45-p - CRYAB (mouse) ▲

Modsite: FSTATSLsPFYLRPP SwissProt Entrez-Gene Orthologous residues CRYAB (human): S45‑p, CRYAB (mouse): S45‑p, CRYAB (rat): S45‑p, CRYAB (rabbit): S45‑p, CRYAB (pig): S45‑p, CRYAB (cow): S45‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  C2C12 (myoblast) Cellular systems studied:  cell lines Species studied:  mouse Comments:  phosphorylation of this site increases in cells carrying the dominant-negative desmin mutant K239fs242; Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes heat_shock increase

S59-p - CRYAB (mouse) ▲

Modsite: PSFLRAPsWIDtGLS SwissProt Entrez-Gene Orthologous residues CRYAB (human): S59‑p, CRYAB (mouse): S59‑p, CRYAB (rat): S59‑p, CRYAB (rabbit): S59‑p, CRYAB (pig): S59‑p, CRYAB (cow): S59‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  C2C12 (myoblast) Cellular systems studied:  cell lines Species studied:  mouse Comments:  phosphorylation of this site increases in cells carrying the dominant-negative desmin mutant K239fs242; Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE P38A (human) pharmacological inhibitor of upstream enzyme, transfection of dominant-negative enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes vinblastine increase SB203580 vinblastine inhibit treatment-induced increase cytochalasin_D increase SB203580 cytochalasin_D inhibit treatment-induced increase heat_shock increase bisindolylmaleimide vinblastine inhibit treatment-induced increase Y27632 vinblastine inhibit treatment-induced increase H-89 vinblastine no effect upon treatment-induced increase bisindolylmaleimide cytochalasin_D no effect upon treatment-induced increase Y27632 cytochalasin_D no effect upon treatment-induced increase H-89 cytochalasin_D inhibit treatment-induced increase Downstream Regulation Effect of modification (process):  cytoskeletal reorganization Comments:  stabilizes actin filaments

T180-p - P38A (mouse) ▲

Modsite: RHtDDEMtGyVAtRW SwissProt Entrez-Gene Orthologous residues P38A (human): T180‑p, P38A iso2 (human): T180‑p, P38A (mouse): T180‑p, P38A iso3 (mouse): T180‑p, P38A (rat): T180‑p, P38A (salmonid): T181‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  C2C12 (myoblast) Cellular systems studied:  cell lines Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes vinblastine increase cytochalasin_D increase heat_shock increase TNF no change compared to control

Y182-p - P38A (mouse) ▲

Modsite: tDDEMtGyVAtRWYR SwissProt Entrez-Gene Orthologous residues P38A (human): Y182‑p, P38A iso2 (human): Y182‑p, P38A (mouse): Y182‑p, P38A iso3 (mouse): Y182‑p, P38A (rat): Y182‑p, P38A (salmonid): Y183‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  C2C12 (myoblast) Cellular systems studied:  cell lines Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes vinblastine increase cytochalasin_D increase heat_shock increase TNF no change compared to control