Banerjee S, et al. (2018) Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2. Proc Natl Acad Sci U S A 115, 8155-8160 29987021

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T25-p - RPT3 (human) ▲

Modsite: LSVsRPQtGLsFLGP SwissProt Entrez-Gene Orthologous residues RPT3 (human): T25‑p, RPT3 iso2 (human): T25‑p, RPT3 (mouse): T25‑p, RPT3 (rat): T25‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes curcumin decrease specific and potent inhibitor of DYRK2