Curated Information
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Home > Curated Information Page > PubMed Id: 16952352
Zeng G, et al. (2006) Tyrosine residues 654 and 670 in beta-catenin are crucial in regulation of Met-beta-catenin interactions. Exp Cell Res 312, 3620-30 16952352
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y654-p - CTNNB1 (human)
Modsite: RNEGVAtyAAAVLFR SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): Y654‑p, CTNNB1 (mouse): Y654‑p, CTNNB1 (rat): Y654‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  JM1 (hepatic)
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase
Downstream Regulation
Effect of modification (function):  activity, induced, molecular association, regulation
Effect of modification (process):  cell growth, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
LEF-1 (human) Disrupts co-immunoprecipitation
Met (human) Disrupts co-immunoprecipitation
CDH1 (human) Disrupts co-immunoprecipitation

Y670-p - CTNNB1 (human)
Modsite: SEDKPQDykKRLsVE SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): Y670‑p, CTNNB1 (mouse): Y670‑p, CTNNB1 (rat): Y670‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  JM1 (hepatic)
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase
Downstream Regulation
Effect of modification (function):  activity, induced, molecular association, regulation
Effect of modification (process):  cell growth, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CDH1 (human) Disrupts co-immunoprecipitation
LEF-1 (human) Disrupts co-immunoprecipitation
Met (human) Disrupts co-immunoprecipitation