Curated Information
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Home > Curated Information Page > PubMed Id: 28501616
Hayashi K, et al. (2017) Identification of phosphorylation sites on β1-adrenergic receptor in the mouse heart. Biochem Biophys Res Commun 488, 362-367 28501616
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S162-p - ADRB1 (mouse)
Modsite: DRYLAITsPFRYQsL SwissProt Entrez-Gene
Orthologous residues
ADRB1 (human): S162‑p, ADRB1 (mouse): S162‑p, ADRB1 (rat): L162‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  HEK293T (epithelial) [ADRB1 (mouse), transfection]
Cellular systems studied:  cell lines
Species studied:  human

S168-p - ADRB1 (mouse)
Modsite: TsPFRYQsLLTRARA SwissProt Entrez-Gene
Orthologous residues
ADRB1 (human): S168‑p, ADRB1 (mouse): S168‑p, ADRB1 (rat): S168‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  HEK293T (epithelial) [ADRB1 (mouse), transfection]
Cellular systems studied:  cell lines
Species studied:  human

S260-p - ADRB1 (mouse)
Modsite: KQVKKIDsCERRFLG SwissProt Entrez-Gene
Orthologous residues
ADRB1 (human): S260‑p, ADRB1 (mouse): S260‑p, ADRB1 (rat): S260‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  HEK293T (epithelial) [ADRB1 (mouse), transfection]
Cellular systems studied:  cell lines
Species studied:  human

S274-p - ADRB1 (mouse)
Modsite: GGPARPPsPEPSPsP SwissProt Entrez-Gene
Orthologous residues
ADRB1 (human): S274‑p, ADRB1 (mouse): S274‑p, ADRB1 (rat): S274‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart, HEK293T (epithelial) [ADRB1 (mouse), transfection]
Cellular systems studied:  cell lines, tissue
Species studied:  human, mouse
Comments:  isoproterenol-treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
isoproterenol increase

S280-p - ADRB1 (mouse)
Modsite: PsPEPSPsPGPPRPA SwissProt Entrez-Gene
Orthologous residues
ADRB1 (human): P286‑p, ADRB1 (mouse): S280‑p, ADRB1 (rat): S280‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart, HEK293T (epithelial) [ADRB1 (mouse), transfection]
Cellular systems studied:  cell lines, tissue
Species studied:  human, mouse
Comments:  isoproterenol-treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
isoproterenol increase

S301-p - ADRB1 (mouse)
Modsite: RSSKRRPsRLVALRE SwissProt Entrez-Gene
Orthologous residues
ADRB1 (human): S312‑p, ADRB1 (mouse): S301‑p, ADRB1 (rat): S301‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  HEK293T (epithelial) [ADRB1 (mouse), transfection]
Cellular systems studied:  cell lines
Species studied:  human

S401-p - ADRB1 (mouse)
Modsite: HGDRPRAsGCLARAG SwissProt Entrez-Gene
Orthologous residues
ADRB1 (human): S412‑p, ADRB1 (mouse): S401‑p, ADRB1 (rat): S401‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  HEK293T (epithelial) [ADRB1 (mouse), transfection]
Cellular systems studied:  cell lines
Species studied:  human

S412-p - ADRB1 (mouse)
Modsite: ARAGPPPsPGAPsDD SwissProt Entrez-Gene
Orthologous residues
ADRB1 (human): S423‑p, ADRB1 (mouse): S412‑p, ADRB1 (rat): S412‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart, HEK293T (epithelial) [ADRB1 (mouse), transfection]
Cellular systems studied:  cell lines, tissue
Species studied:  human, mouse
Comments:  isoproterenol-treated

S417-p - ADRB1 (mouse)
Modsite: PPsPGAPsDDDDDDA SwissProt Entrez-Gene
Orthologous residues
ADRB1 (human): S428‑p, ADRB1 (mouse): S417‑p, ADRB1 (rat): S417‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart, HEK293T (epithelial) [ADRB1 (mouse), transfection]
Cellular systems studied:  cell lines, tissue
Species studied:  human, mouse
Comments:  isoproterenol-treated

S450-p - ADRB1 (mouse)
Modsite: TTTVDSDssLDEPGR SwissProt Entrez-Gene
Orthologous residues
ADRB1 (human): S461‑p, ADRB1 (mouse): S450‑p, ADRB1 (rat): S450‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart, HEK293T (epithelial) [ADRB1 (mouse), transfection]
Cellular systems studied:  cell lines, tissue
Species studied:  human, mouse
Comments:  isoproterenol-treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
isoproterenol increase

S451-p - ADRB1 (mouse)
Modsite: TTVDSDssLDEPGRQ SwissProt Entrez-Gene
Orthologous residues
ADRB1 (human): S462‑p, ADRB1 (mouse): S451‑p, ADRB1 (rat): S451‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart, HEK293T (epithelial) [ADRB1 (mouse), transfection]
Cellular systems studied:  cell lines, tissue
Species studied:  human, mouse
Comments:  isoproterenol-treated

S462-p - ADRB1 (mouse)
Modsite: PGRQGFSsESKV___ SwissProt Entrez-Gene
Orthologous residues
ADRB1 (human): S473‑p, ADRB1 (mouse): S462‑p, ADRB1 (rat): S462‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart, HEK293T (epithelial) [ADRB1 (mouse), transfection]
Cellular systems studied:  cell lines, tissue
Species studied:  human, mouse
Comments:  isoproterenol-treated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
isoproterenol increase