Conkright JJ, et al. (2010) Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C. Am J Respir Cell Mol Biol 42, 181-9 19423771

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K6-ub - SFTPC (human) ▲

Modsite: __MDVGSkEVLMESP SwissProt Entrez-Gene Orthologous residues SFTPC (human): K6‑ub, SFTPC (mouse): K6‑ub, SFTPC (rat): K6‑ub, SFTPC (pig): ‑ Characterization Methods used to characterize site in vivo:  electrophoretic mobility shift, immunoprecipitation, modification-specific antibody, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes UBIQUITIN LIGASE NEDD4 (human) co-immunoprecipitation weak binding UBIQUITIN LIGASE NEDD4L (human) co-immunoprecipitation, transfection of wild-type enzyme Downstream Regulation Effect of modification (function):  protein processing Effect of modification (process):  endocytosis, induced Comments:  processing of proSFTPC to mature peptide