Curated Information
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Home > Curated Information Page > PubMed Id: 19423771
Conkright JJ, et al. (2010) Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C. Am J Respir Cell Mol Biol 42, 181-9 19423771
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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K6-ub - SFTPC (human)
Modsite: __MDVGSkEVLMESP SwissProt Entrez-Gene
Orthologous residues
SFTPC (human): K6‑ub, SFTPC (mouse): K6‑ub, SFTPC (rat): K6‑ub, SFTPC (pig):
Characterization
Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, modification-specific antibody, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
UBIQUITIN LIGASE NEDD4 (human) co-immunoprecipitation weak binding
UBIQUITIN LIGASE NEDD4L (human) co-immunoprecipitation, transfection of wild-type enzyme
Downstream Regulation
Effect of modification (function):  protein processing
Effect of modification (process):  endocytosis, induced
Comments:  processing of proSFTPC to mature peptide