Curated Information
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Home > Curated Information Page > PubMed Id: 28495796
Sarker R, et al. (2017) Phosphorylation of NHE3-S(719) regulates NHE3 activity through the formation of multiple signaling complexes. Mol Biol Cell 28, 1754-1767 28495796
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S719-p - NHE3 (rabbit)
Modsite: KERELELsDPEEAPD SwissProt Entrez-Gene
Orthologous residues
NHE3 (human): S718‑p, NHE3 (mouse): S714‑p, NHE3 (rat): S716‑p, NHE3 (rabbit): S719‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, western blotting
Disease tissue studied:  colorectal carcinoma
Relevant cell lines - cell types - tissues:  C2BBe1 (intestinal)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A1 (human)
KINASE CK2B (human)
Downstream Regulation
Effect of modification (function):  activity, inhibited, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SNX27 (human) Induces pull-down assay