Karvonen U, Jänne OA, Palvimo JJ (2006) Androgen receptor regulates nuclear trafficking and nuclear domain residency of corepressor HDAC7 in a ligand-dependent fashion. Exp Cell Res 312, 3165-83 16860317

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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K631-ac - AR (human) ▲

Modsite: GMTLGARkLkkLGNL SwissProt Entrez-Gene Orthologous residues AR (human): K631‑ac, AR iso3 (human): ‑, AR (mouse): K610‑ac, AR (rat): K613‑ac Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  HeLa (cervical), LNCaP (prostate cell) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes DEACETYLASE HDAC7 (human) pharmacological inhibitor of upstream enzyme, microscopy-colocalization, co-immunoprecipitation, transfection of wild-type enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes trichostatin_A increase Downstream Regulation Effect of modification (process):  transcription, altered

K633-ac - AR (human) ▲

Modsite: TLGARkLkkLGNLKL SwissProt Entrez-Gene Orthologous residues AR (human): K633‑ac, AR iso3 (human): ‑, AR (mouse): K612‑ac, AR (rat): K615‑ac Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  HeLa (cervical), LNCaP (prostate cell) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes DEACETYLASE HDAC7 (human) pharmacological inhibitor of upstream enzyme, microscopy-colocalization, co-immunoprecipitation, transfection of wild-type enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes trichostatin_A increase Downstream Regulation Effect of modification (process):  transcription, altered

K634-ac - AR (human) ▲

Modsite: LGARkLkkLGNLKLQ SwissProt Entrez-Gene Orthologous residues AR (human): K634‑ac, AR iso3 (human): ‑, AR (mouse): K613‑ac, AR (rat): K616‑ac Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  HeLa (cervical), LNCaP (prostate cell) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes DEACETYLASE HDAC7 (human) pharmacological inhibitor of upstream enzyme, microscopy-colocalization, co-immunoprecipitation, transfection of wild-type enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes trichostatin_A increase Downstream Regulation Effect of modification (process):  transcription, altered