Seibold A, et al. (2000) Localization of the sites mediating desensitization of the beta(2)-adrenergic receptor by the GRK pathway. Mol Pharmacol 58, 1162-73 11040066

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S355-p - ADRB2 (human) ▲

Modsite: KAyGNGyssNGNtGE SwissProt Entrez-Gene Orthologous residues ADRB2 (human): S355‑p, ADRB2 (mouse): S355‑p, ADRB2 (rat): S355‑p, ADRB2 (hamster): S355‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes racepinefrine increase Downstream Regulation Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered

S356-p - ADRB2 (human) ▲

Modsite: AyGNGyssNGNtGEQ SwissProt Entrez-Gene Orthologous residues ADRB2 (human): S356‑p, ADRB2 (mouse): S356‑p, ADRB2 (rat): S356‑p, ADRB2 (hamster): S356‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes racepinefrine increase Downstream Regulation Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered

S364-p - ADRB2 (human) ▲

Modsite: NGNtGEQsGYHVEQE SwissProt Entrez-Gene Orthologous residues ADRB2 (human): S364‑p, ADRB2 (mouse): N369‑p, ADRB2 (rat): S369‑p, ADRB2 (hamster): S369‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes racepinefrine increase Downstream Regulation Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered