Curated Information
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Home > Curated Information Page > PubMed Id: 16829026
Mouton V, et al. (2007) Evaluation of the role of protein kinase Czeta in insulin-induced heart 6-phosphofructo-2-kinase activation. Cell Signal 19, 52-61 16829026
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S473-p - Akt1 (rat)
Modsite: RPHFPQFsYSASGTA SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

T410-p - PKCZ (rat)
Modsite: GPGDTTStFCGTPNY SwissProt Entrez-Gene
Orthologous residues
PKCZ (human): T410‑p, PKCZ iso2 (human): T227‑p, PKCZ iso3 (human): T306‑p, PKCZ (mouse): T410‑p, PKCZ (rat): T410‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

S467-p - PFKFB2 (cow)
Modsite: PVRMRRNsFTPLSSS SwissProt Entrez-Gene
Orthologous residues
PFKFB2 (human): S466‑p, PFKFB2 iso2 (human): , PFKFB2 (mouse): S469‑p, PFKFB2 iso3 (mouse): S468‑p, PFKFB2 (rat): S469‑p, PFKFB2 (cow): S467‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)

T476-p - PFKFB2 (cow)
Modsite: TPLSSSNtIRRPRNY SwissProt Entrez-Gene
Orthologous residues
PFKFB2 (human): T475‑p, PFKFB2 iso2 (human): , PFKFB2 (mouse): T478‑p, PFKFB2 iso3 (mouse): T477‑p, PFKFB2 (rat): T478‑p, PFKFB2 (cow): T476‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCZ (human)

S484-p - PFKFB2 (cow)
Modsite: IRRPRNYsVGSRPLQ SwissProt Entrez-Gene
Orthologous residues
PFKFB2 (human): S483‑p, PFKFB2 iso2 (human): , PFKFB2 (mouse): S486‑p, PFKFB2 iso3 (mouse): S485‑p, PFKFB2 (rat): S486‑p, PFKFB2 (cow): S484‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)