Lickert H, Bauer A, Kemler R, Stappert J (2000) Casein kinase II phosphorylation of E-cadherin increases E-cadherin/beta-catenin interaction and strengthens cell-cell adhesion. J Biol Chem 275, 5090-5 10671552

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S840-p - CDH1 (mouse) ▲
Modsite: LVFDYEGsGsEAAsL SwissProt Entrez-Gene Orthologous residues CDH1 (human): S838‑p, CDH1 (mouse): S840‑p, CDH1 (rat): S842‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE CK2A1 (human)

S849-p - CDH1 (mouse) ▲
Modsite: sEAAsLssLNSsEsD SwissProt Entrez-Gene Orthologous residues CDH1 (human): S847‑p, CDH1 (mouse): S849‑p, CDH1 (rat): S851‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE GSK3B (human)

S853-p - CDH1 (mouse) ▲

Modsite: sLssLNSsEsDQDQD SwissProt Entrez-Gene Orthologous residues CDH1 (human): S851‑p, CDH1 (mouse): S853‑p, CDH1 (rat): S855‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE CK2A1 (human) Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  cell adhesion, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays CTNNB1 (human) Induces functional assay, in vitro

S855-p - CDH1 (mouse) ▲

Modsite: ssLNSsEsDQDQDYD SwissProt Entrez-Gene Orthologous residues CDH1 (human): S853‑p, CDH1 (mouse): S855‑p, CDH1 (rat): S857‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE CK2A1 (human) Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  cell adhesion, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays CTNNB1 (human) Induces functional assay, in vitro