Penela P, Elorza A, Sarnago S, Mayor F (2001) Beta-arrestin- and c-Src-dependent degradation of G-protein-coupled receptor kinase 2. EMBO J 20, 5129-38 11566877

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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Y13-p - GRK2 (human) ▲

Modsite: AVLADVSyLMAMEkS SwissProt Entrez-Gene Orthologous residues GRK2 (human): Y13‑p, GRK2 (mouse): Y13‑p, GRK2 (rat): Y13‑p, GRK2 (cow): Y13‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  COS (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE Src (human) transfection of constitutively active enzyme, transfection of inactive enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes isoproterenol increase Downstream Regulation Effect of modification (function):  protein degradation

Y86-p - GRK2 (human) ▲

Modsite: ARPLVEFyEEIKKyE SwissProt Entrez-Gene Orthologous residues GRK2 (human): Y86‑p, GRK2 (mouse): Y86‑p, GRK2 (rat): Y86‑p, GRK2 (cow): Y86‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  COS (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE Src (human) transfection of constitutively active enzyme, transfection of inactive enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes isoproterenol increase Downstream Regulation Effect of modification (function):  protein degradation

Y92-p - GRK2 (human) ▲

Modsite: FyEEIKKyEkLETEE SwissProt Entrez-Gene Orthologous residues GRK2 (human): Y92‑p, GRK2 (mouse): Y92‑p, GRK2 (rat): Y92‑p, GRK2 (cow): Y92‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  COS (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE Src (human) transfection of constitutively active enzyme, transfection of inactive enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes isoproterenol increase Downstream Regulation Effect of modification (function):  protein degradation