Axelsen LN, et al. (2006) Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123). J Mol Cell Cardiol 40, 790-8 16678851

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S255-p - GJA1 (rat) ▲

Modsite: HATTGPLsPskDCGs SwissProt Entrez-Gene Orthologous residues GJA1 (human): S255‑p, GJA1 (mouse): S255‑p, GJA1 (rat): S255‑p, GJA1 (rabbit): S255‑p, GJA1 (pig): S255‑p, GJA1 (hamster): N255‑p, GJA1 (cow): S256‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  tissue Species studied:  rat

S257-p - GJA1 (rat) ▲

Modsite: TTGPLsPskDCGsPk SwissProt Entrez-Gene Orthologous residues GJA1 (human): A257‑p, GJA1 (mouse): S257‑p, GJA1 (rat): S257‑p, GJA1 (rabbit): S257‑p, GJA1 (pig): S257‑p, GJA1 (hamster): S257‑p, GJA1 (cow): S258‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  tissue Species studied:  rat

S262-p - GJA1 (rat) ▲

Modsite: sPskDCGsPkyAyFN SwissProt Entrez-Gene Orthologous residues GJA1 (human): S262‑p, GJA1 (mouse): S262‑p, GJA1 (rat): S262‑p, GJA1 (rabbit): S262‑p, GJA1 (pig): S262‑p, GJA1 (hamster): S262‑p, GJA1 (cow): S263‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  tissue Species studied:  rat

S296-p - GJA1 (rat) ▲

Modsite: VTGDRNNssCRNYNk SwissProt Entrez-Gene Orthologous residues GJA1 (human): S296‑p, GJA1 (mouse): S296‑p, GJA1 (rat): S296‑p, GJA1 (rabbit): S296‑p, GJA1 (pig): S296‑p, GJA1 (hamster): S296‑p, GJA1 (cow): S297‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  tissue Species studied:  rat

S297-p - GJA1 (rat) ▲

Modsite: TGDRNNssCRNYNkQ SwissProt Entrez-Gene Orthologous residues GJA1 (human): S297‑p, GJA1 (mouse): S297‑p, GJA1 (rat): S297‑p, GJA1 (rabbit): S297‑p, GJA1 (pig): S297‑p, GJA1 (hamster): S297‑p, GJA1 (cow): S298‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ischemia decrease rotigaptide ischemia inhibit treatment-induced decrease

S306-p - GJA1 (rat) ▲

Modsite: RNYNkQAsEQNWANy SwissProt Entrez-Gene Orthologous residues GJA1 (human): S306‑p, GJA1 (mouse): S306‑p, GJA1 (rat): S306‑p, GJA1 (rabbit): S306‑p, GJA1 (pig): S306‑p, GJA1 (hamster): S306‑p, GJA1 (cow): S307‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ischemia decrease

S325-p - GJA1 (rat) ▲

Modsite: NRMGQAGstIsNsHA SwissProt Entrez-Gene Orthologous residues GJA1 (human): S325‑p, GJA1 (mouse): S325‑p, GJA1 (rat): S325‑p, GJA1 (rabbit): S325‑p, GJA1 (pig): S325‑p, GJA1 (hamster): S325‑p, GJA1 (cow): S326‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  tissue Species studied:  rat

S328-p - GJA1 (rat) ▲

Modsite: GQAGstIsNsHAQPF SwissProt Entrez-Gene Orthologous residues GJA1 (human): S328‑p, GJA1 (mouse): S328‑p, GJA1 (rat): S328‑p, GJA1 (rabbit): S328‑p, GJA1 (pig): S328‑p, GJA1 (hamster): S328‑p, GJA1 (cow): S329‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  tissue Species studied:  rat

S330-p - GJA1 (rat) ▲

Modsite: AGstIsNsHAQPFDF SwissProt Entrez-Gene Orthologous residues GJA1 (human): S330‑p, GJA1 (mouse): S330‑p, GJA1 (rat): S330‑p, GJA1 (rabbit): S330‑p, GJA1 (pig): S330‑p, GJA1 (hamster): S330‑p, GJA1 (cow): S331‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ischemia increase after 7 min of ischemia ischemia decrease after 30 min of ischemia

S364-p - GJA1 (rat) ▲

Modsite: AIVDQRPssRAssRA SwissProt Entrez-Gene Orthologous residues GJA1 (human): S364‑p, GJA1 (mouse): S364‑p, GJA1 (rat): S364‑p, GJA1 (rabbit): S364‑p, GJA1 (pig): S364‑p, GJA1 (hamster): S364‑p, GJA1 (cow): S365‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  tissue Species studied:  rat Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCA (human) KINASE PKCE (human)

S365-p - GJA1 (rat) ▲

Modsite: IVDQRPssRAssRAs SwissProt Entrez-Gene Orthologous residues GJA1 (human): S365‑p, GJA1 (mouse): S365‑p, GJA1 (rat): S365‑p, GJA1 (rabbit): S365‑p, GJA1 (pig): S365‑p, GJA1 (hamster): S365‑p, GJA1 (cow): S366‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  tissue Species studied:  rat Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCA (human) KINASE PKCE (human)

S368-p - GJA1 (rat) ▲

Modsite: QRPssRAssRAssRP SwissProt Entrez-Gene Orthologous residues GJA1 (human): S368‑p, GJA1 (mouse): S368‑p, GJA1 (rat): S368‑p, GJA1 (rabbit): S368‑p, GJA1 (pig): S368‑p, GJA1 (hamster): S368‑p, GJA1 (cow): S369‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  tissue Species studied:  rat Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCA (human) KINASE PKCE (human) Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ischemia decrease rotigaptide ischemia inhibit treatment-induced decrease

S369-p - GJA1 (rat) ▲

Modsite: RPssRAssRAssRPR SwissProt Entrez-Gene Orthologous residues GJA1 (human): S369‑p, GJA1 (mouse): S369‑p, GJA1 (rat): S369‑p, GJA1 (rabbit): S369‑p, GJA1 (pig): S369‑p, GJA1 (hamster): S369‑p, GJA1 (cow): S370‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  tissue Species studied:  rat Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCA (human) KINASE PKCE (human)

S372-p - GJA1 (rat) ▲

Modsite: sRAssRAssRPRPDD SwissProt Entrez-Gene Orthologous residues GJA1 (human): S372‑p, GJA1 (mouse): S372‑p, GJA1 (rat): S372‑p, GJA1 (rabbit): S372‑p, GJA1 (pig): S372‑p, GJA1 (hamster): S372‑p, GJA1 (cow): S373‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  tissue Species studied:  rat Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCE (human) KINASE PKCA (human)

S373-p - GJA1 (rat) ▲

Modsite: RAssRAssRPRPDDL SwissProt Entrez-Gene Orthologous residues GJA1 (human): S373‑p, GJA1 (mouse): S373‑p, GJA1 (rat): S373‑p, GJA1 (rabbit): S373‑p, GJA1 (pig): S373‑p, GJA1 (hamster): S373‑p, GJA1 (cow): S374‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  heart Cellular systems studied:  tissue Species studied:  rat Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCE (human) KINASE PKCA (human)