Jiang X, Wang Y (2006) Acetylation and phosphorylation of high-mobility group A1 proteins in PC-3 human tumor cells. Biochemistry 45, 7194-201 16752910

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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K15-ac - HMGA1 (human) ▲

Modsite: ssQPLAskQEkDGtE SwissProt Entrez-Gene Orthologous residues HMGA1 (human): K15‑ac, HMGA1 iso2 (human): K15‑ac, HMGA1 iso3 (human): K15‑ac, HMGA1 (mouse): K15‑ac, HMGA1 iso2 (mouse): K15‑ac, HMGA1 iso3 (mouse): K15‑ac, HMGA1 (rat): K15‑ac Characterization Methods used to characterize site in vivo:  mass spectrometry Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  PC3 (prostate cell) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes butyrate increase

S36-p - HMGA1 (human) ▲

Modsite: PRkQPPVsPGtALVG SwissProt Entrez-Gene Orthologous residues HMGA1 (human): S36‑p, HMGA1 iso2 (human): ‑, HMGA1 iso3 (human): S36‑p, HMGA1 (mouse): S36‑p, HMGA1 iso2 (mouse): ‑, HMGA1 iso3 (mouse): S36‑p, HMGA1 (rat): S36‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  PC3 (prostate cell) Cellular systems studied:  cell lines Species studied:  human

T53-p - HMGA1 (human) ▲

Modsite: kEPsEVPtPkRPrGr SwissProt Entrez-Gene Orthologous residues HMGA1 (human): T53‑p, HMGA1 iso2 (human): T42‑p, HMGA1 iso3 (human): T53‑p, HMGA1 (mouse): T53‑p, HMGA1 iso2 (mouse): T42‑p, HMGA1 iso3 (mouse): T53‑p, HMGA1 (rat): T53‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  PC3 (prostate cell) Cellular systems studied:  cell lines Species studied:  human

T78-p - HMGA1 (human) ▲

Modsite: ktrkttttPGrkPrG SwissProt Entrez-Gene Orthologous residues HMGA1 (human): T78‑p, HMGA1 iso2 (human): T67‑p, HMGA1 iso3 (human): A75‑p, HMGA1 (mouse): A78‑p, HMGA1 iso2 (mouse): A67‑p, HMGA1 iso3 (mouse): A78‑p, HMGA1 (rat): T78‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  PC3 (prostate cell) Cellular systems studied:  cell lines Species studied:  human

S99-p - HMGA1 (human) ▲

Modsite: KEEEEGIsQEssEEE SwissProt Entrez-Gene Orthologous residues HMGA1 (human): S99‑p, HMGA1 iso2 (human): S88‑p, HMGA1 iso3 (human): P149‑p, HMGA1 (mouse): S99‑p, HMGA1 iso2 (mouse): S88‑p, HMGA1 iso3 (mouse): S98‑p, HMGA1 (rat): S99‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  PC3 (prostate cell) Cellular systems studied:  cell lines Species studied:  human

S102-p - HMGA1 (human) ▲

Modsite: EEGIsQEssEEEQ__ SwissProt Entrez-Gene Orthologous residues HMGA1 (human): S102‑p, HMGA1 iso2 (human): S91‑p, HMGA1 iso3 (human): C174‑p, HMGA1 (mouse): S102‑p, HMGA1 iso2 (mouse): S91‑p, HMGA1 iso3 (mouse): S101‑p, HMGA1 (rat): S102‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  PC3 (prostate cell) Cellular systems studied:  cell lines Species studied:  human

S103-p - HMGA1 (human) ▲

Modsite: EGIsQEssEEEQ___ SwissProt Entrez-Gene Orthologous residues HMGA1 (human): S103‑p, HMGA1 iso2 (human): S92‑p, HMGA1 iso3 (human): P175‑p, HMGA1 (mouse): S103‑p, HMGA1 iso2 (mouse): S92‑p, HMGA1 iso3 (mouse): S102‑p, HMGA1 (rat): S103‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  PC3 (prostate cell) Cellular systems studied:  cell lines Species studied:  human

K15-ac - HMGA1 iso2 (human) ▲

Modsite: SSQPLASkQEkDGtE SwissProt Entrez-Gene Orthologous residues HMGA1 (human): K15‑ac, HMGA1 iso2 (human): K15‑ac, HMGA1 iso3 (human): K15‑ac, HMGA1 (mouse): K15‑ac, HMGA1 iso2 (mouse): K15‑ac, HMGA1 iso3 (mouse): K15‑ac, HMGA1 (rat): K15‑ac Characterization Methods used to characterize site in vivo:  mass spectrometry Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  PC3 (prostate cell) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes butyrate increase

T42-p - HMGA1 iso2 (human) ▲

Modsite: kEPsEVPtPkrPrGr SwissProt Entrez-Gene Orthologous residues HMGA1 (human): T53‑p, HMGA1 iso2 (human): T42‑p, HMGA1 iso3 (human): T53‑p, HMGA1 (mouse): T53‑p, HMGA1 iso2 (mouse): T42‑p, HMGA1 iso3 (mouse): T53‑p, HMGA1 (rat): T53‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  PC3 (prostate cell) Cellular systems studied:  cell lines Species studied:  human

T67-p - HMGA1 iso2 (human) ▲

Modsite: kTRkTTTtPGRkPrG SwissProt Entrez-Gene Orthologous residues HMGA1 (human): T78‑p, HMGA1 iso2 (human): T67‑p, HMGA1 iso3 (human): A75‑p, HMGA1 (mouse): A78‑p, HMGA1 iso2 (mouse): A67‑p, HMGA1 iso3 (mouse): A78‑p, HMGA1 (rat): T78‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  PC3 (prostate cell) Cellular systems studied:  cell lines Species studied:  human

S88-p - HMGA1 iso2 (human) ▲

Modsite: kEEEEGIsQEssEEE SwissProt Entrez-Gene Orthologous residues HMGA1 (human): S99‑p, HMGA1 iso2 (human): S88‑p, HMGA1 iso3 (human): P149‑p, HMGA1 (mouse): S99‑p, HMGA1 iso2 (mouse): S88‑p, HMGA1 iso3 (mouse): S98‑p, HMGA1 (rat): S99‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  PC3 (prostate cell) Cellular systems studied:  cell lines Species studied:  human

S91-p - HMGA1 iso2 (human) ▲

Modsite: EEGIsQEssEEEQ__ SwissProt Entrez-Gene Orthologous residues HMGA1 (human): S102‑p, HMGA1 iso2 (human): S91‑p, HMGA1 iso3 (human): C174‑p, HMGA1 (mouse): S102‑p, HMGA1 iso2 (mouse): S91‑p, HMGA1 iso3 (mouse): S101‑p, HMGA1 (rat): S102‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  PC3 (prostate cell) Cellular systems studied:  cell lines Species studied:  human

S92-p - HMGA1 iso2 (human) ▲

Modsite: EGIsQEssEEEQ___ SwissProt Entrez-Gene Orthologous residues HMGA1 (human): S103‑p, HMGA1 iso2 (human): S92‑p, HMGA1 iso3 (human): P175‑p, HMGA1 (mouse): S103‑p, HMGA1 iso2 (mouse): S92‑p, HMGA1 iso3 (mouse): S102‑p, HMGA1 (rat): S103‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  PC3 (prostate cell) Cellular systems studied:  cell lines Species studied:  human