Yoon YS, et al. (2009) Salt-inducible kinase regulates hepatic lipogenesis by controlling SREBP-1c phosphorylation. J Biol Chem 284, 10446-52 19244231

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S265-p - SREBP-1 iso4 (mouse) ▲

Modsite: AIEKRYRssINDKIV SwissProt Entrez-Gene Orthologous residues SREBP‑1 (human): S337‑p, SREBP‑1 iso3 (human): S313‑p, SREBP‑1 iso4 (human): S367‑p, SREBP‑1 (mouse): S331‑p, SREBP‑1 iso4 (mouse): S265‑p, SREBP‑1 (rat): S331‑p, SREBP‑1 iso1 (rat): S307‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Disease tissue studied:  liver cancer Relevant cell lines - cell types - tissues:  HepG2 (hepatic) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  transcription, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays Disrupts Comments:  regulates hepatic lipogenesis

S266-p - SREBP-1 iso4 (mouse) ▲

Modsite: IEKRYRssINDKIVE SwissProt Entrez-Gene Orthologous residues SREBP‑1 (human): S338‑p, SREBP‑1 iso3 (human): S314‑p, SREBP‑1 iso4 (human): S368‑p, SREBP‑1 (mouse): S332‑p, SREBP‑1 iso4 (mouse): S266‑p, SREBP‑1 (rat): S332‑p, SREBP‑1 iso1 (rat): S308‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Disease tissue studied:  liver cancer Relevant cell lines - cell types - tissues:  HepG2 (hepatic) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  transcription, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays Disrupts Comments:  regulates hepatic lipogenesis

S329-p - SREBP-1 iso4 (mouse) ▲

Modsite: KSLKDLVsACGSGGG SwissProt Entrez-Gene Orthologous residues SREBP‑1 (human): S402‑p, SREBP‑1 iso3 (human): S378‑p, SREBP‑1 iso4 (human): S432‑p, SREBP‑1 (mouse): S395‑p, SREBP‑1 iso4 (mouse): S329‑p, SREBP‑1 (rat): S395‑p, SREBP‑1 iso1 (rat): S371‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Disease tissue studied:  liver cancer Relevant cell lines - cell types - tissues:  HepG2 (hepatic) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE SIK (human) Downstream Regulation Effect of modification (function):  activity, inhibited, molecular association, regulation Effect of modification (process):  transcription, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays Disrupts Comments:  regulates hepatic lipogenesis