Hsu LJ, et al. (2009) Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1. J Biol Chem 284, 16049-59 19366691

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Y33-p - WWOX (human) ▲

Modsite: TTkDGWVyYANHTEE SwissProt Entrez-Gene Orthologous residues WWOX (human): Y33‑p, WWOX (mouse): Y33‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  colorectal cancer, colorectal carcinoma, fibrosarcoma of soft tissue Relevant cell lines - cell types - tissues:  HCT116 (intestinal), L929 (fibroblast) Cellular systems studied:  cell lines Species studied:  human, mouse Downstream Regulation Effect of modification (function):  intracellular localization, molecular association, regulation Effect of modification (process):  apoptosis, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays HYAL2 (mouse) Induces yeast two-hybrid, co-immunoprecipitation, microscopy-colocalization Comments:  induced by TGF-beta1