Anggono V, et al. (2006) Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis. Nat Neurosci 9, 752-60 16648848

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S774-p - DYN1 (rat) ▲

Modsite: SVPAGRRsPTSsPTP SwissProt Entrez-Gene Orthologous residues DYN1 (human): S774‑p, DYN1 iso2 (human): S774‑p, DYN1 iso3 (human): S774‑p, DYN1 (mouse): S774‑p, DYN1 iso3 (mouse): S774‑p, DYN1 iso4 (mouse): S774‑p, DYN1 iso6 (mouse): S770‑p, DYN1 (rat): S774‑p, DYN1 iso2 (rat): S774‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain, neuron:synaptosome-brain Cellular systems studied:  primary cultured cells Species studied:  rat Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays PACSIN1 (rat) Disrupts co-immunoprecipitation, in vitro Comments:  regulates synaptic vesicle endocytosis

S778-p - DYN1 (rat) ▲

Modsite: GRRsPTSsPTPQRRA SwissProt Entrez-Gene Orthologous residues DYN1 (human): S778‑p, DYN1 iso2 (human): S778‑p, DYN1 iso3 (human): S778‑p, DYN1 (mouse): S778‑p, DYN1 iso3 (mouse): S778‑p, DYN1 iso4 (mouse): S778‑p, DYN1 iso6 (mouse): S774‑p, DYN1 (rat): S778‑p, DYN1 iso2 (rat): S778‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain, neuron:synaptosome-brain Cellular systems studied:  primary cultured cells Species studied:  rat Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays PACSIN1 (rat) Disrupts co-immunoprecipitation, in vitro Comments:  regulates synaptic vesicle endocytosis