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Home > Curated Information Page > PubMed Id: 16287840
Faiola F, et al. (2005) Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. Mol Cell Biol 25, 10220-34 16287840
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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K143-ac - Myc (human)
Modsite: SGFSAAAkLVSEkLA SwissProt Entrez-Gene
Orthologous residues
Myc (human): K143‑ac, Myc iso2 (human): K158‑ac, Myc (mouse): K144‑ac, Myc (rat): K144‑ac
Characterization
Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro), mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)

K148-ac - Myc (human)
Modsite: AAkLVSEkLAsYQAA SwissProt Entrez-Gene
Orthologous residues
Myc (human): K148‑ac, Myc iso2 (human): K163‑ac, Myc (mouse): K149‑ac, Myc (rat): K149‑ac
Characterization
Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro), mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
ACETYLTRANSFERASE p300 (human) transfection of wild-type enzyme

K157-ac - Myc (human)
Modsite: AsYQAARkDSGsPNP SwissProt Entrez-Gene
Orthologous residues
Myc (human): K157‑ac, Myc iso2 (human): K172‑ac, Myc (mouse): K158‑ac, Myc (rat): K158‑ac
Characterization
Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro), mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
ACETYLTRANSFERASE p300 (human) transfection of wild-type enzyme

K275-ac - Myc (human)
Modsite: EKRQAPGkRsEsGsP SwissProt Entrez-Gene
Orthologous residues
Myc (human): K275‑ac, Myc iso2 (human): K290‑ac, Myc (mouse): K275‑ac, Myc (rat): K275‑ac
Characterization
Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro), mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)

K317-ac - Myc (human)
Modsite: AAPPSTRkDYPAAkR SwissProt Entrez-Gene
Orthologous residues
Myc (human): K317‑ac, Myc iso2 (human): K332‑ac, Myc (mouse): K317‑ac, Myc (rat): K317‑ac
Characterization
Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro), mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
ACETYLTRANSFERASE p300 (human) transfection of wild-type enzyme

K323-ac - Myc (human)
Modsite: RkDYPAAkRVkLDsV SwissProt Entrez-Gene
Orthologous residues
Myc (human): K323‑ac, Myc iso2 (human): K338‑ac, Myc (mouse): K323‑ac, Myc (rat): K323‑ac
Characterization
Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro), mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
ACETYLTRANSFERASE p300 (human) transfection of wild-type enzyme

K371-ac - Myc (human)
Modsite: RQRRNELkRsFFALR SwissProt Entrez-Gene
Orthologous residues
Myc (human): K371‑ac, Myc iso2 (human): K386‑ac, Myc (mouse): K371‑ac, Myc (rat): K371‑ac
Characterization
Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro), mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)