Hinchliffe KA, Irvine RF (2006) Regulation of type II PIP kinase by PKD phosphorylation. Cell Signal 18, 1906-13 16563698

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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T376-p - PIP4K2A (human) ▲

Modsite: KAAHAAktVKHGAGA SwissProt Entrez-Gene Orthologous residues PIP4K2A (human): T376‑p, PIP4K2A (mouse): T376‑p, PIP4K2A (rat): T376‑p Characterization Methods used to characterize site in vivo:  2D analysis, [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  HeLa (cervical), RAW 264 (macrophage) Cellular systems studied:  cell lines Species studied:  human, mouse Enzymes shown to modify site in vitro:  Type Enzyme KINASE PRKD1 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PRKD1 (human) activation of upstream enzyme, pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes H2O2 increase Go_6976 decrease Downstream Regulation Effect of modification (function):  enzymatic activity, inhibited

S910-p - PRKD1 (human) ▲

Modsite: KALGERVsIL_____ SwissProt Entrez-Gene Orthologous residues PRKD1 (human): S910‑p, PRKD1 (mouse): S916‑p, PRKD1 (rat): S916‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  HeLa (cervical), RAW 264 (macrophage) Cellular systems studied:  cell lines Species studied:  human, mouse Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PRKD1 (human) activation of upstream enzyme Downstream Regulation Effect of modification (function):  enzymatic activity, induced