Yogo K, et al. (2006) PKA implicated in the phosphorylation of Cx43 induced by stimulation with FSH in rat granulosa cells. J Reprod Dev 52, 321-8 16474210

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S365-p - GJA1 (rat) ▲

Modsite: IVDQRPssRAssRAs SwissProt Entrez-Gene Orthologous residues GJA1 (human): S365‑p, GJA1 (mouse): S365‑p, GJA1 (rat): S365‑p, GJA1 (rabbit): S365‑p, GJA1 (pig): S365‑p, GJA1 (hamster): S365‑p, GJA1 (cow): S366‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  preovulatory follicle granulosa Cellular systems studied:  primary cultured cells Species studied:  rat Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKACA (human) pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes urofollitropin increase H-89 urofollitropin inhibit treatment-induced increase PD98059 urofollitropin no effect upon treatment-induced increase

S368-p - GJA1 (rat) ▲

Modsite: QRPssRAssRAssRP SwissProt Entrez-Gene Orthologous residues GJA1 (human): S368‑p, GJA1 (mouse): S368‑p, GJA1 (rat): S368‑p, GJA1 (rabbit): S368‑p, GJA1 (pig): S368‑p, GJA1 (hamster): S368‑p, GJA1 (cow): S369‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  preovulatory follicle granulosa Cellular systems studied:  primary cultured cells Species studied:  rat Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKACA (human) pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes urofollitropin increase H-89 urofollitropin inhibit treatment-induced increase PD98059 urofollitropin no effect upon treatment-induced increase

S369-p - GJA1 (rat) ▲

Modsite: RPssRAssRAssRPR SwissProt Entrez-Gene Orthologous residues GJA1 (human): S369‑p, GJA1 (mouse): S369‑p, GJA1 (rat): S369‑p, GJA1 (rabbit): S369‑p, GJA1 (pig): S369‑p, GJA1 (hamster): S369‑p, GJA1 (cow): S370‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  preovulatory follicle granulosa Cellular systems studied:  primary cultured cells Species studied:  rat Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKACA (human) pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes urofollitropin increase H-89 urofollitropin inhibit treatment-induced increase PD98059 urofollitropin no effect upon treatment-induced increase

S373-p - GJA1 (rat) ▲

Modsite: RAssRAssRPRPDDL SwissProt Entrez-Gene Orthologous residues GJA1 (human): S373‑p, GJA1 (mouse): S373‑p, GJA1 (rat): S373‑p, GJA1 (rabbit): S373‑p, GJA1 (pig): S373‑p, GJA1 (hamster): S373‑p, GJA1 (cow): S374‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  preovulatory follicle granulosa Cellular systems studied:  primary cultured cells Species studied:  rat Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKACA (human) pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes urofollitropin increase H-89 urofollitropin inhibit treatment-induced increase PD98059 urofollitropin no effect upon treatment-induced increase