Zhang N, et al. (2018) cPKCγ alleviates ischemic injury through modulating synapsin Ia/b phosphorylation in neurons of mice. Brain Res Bull 142, 156-162 30016727

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S9-p - SYN1 (mouse) ▲

Modsite: NYLRRRLsDsNFMAN SwissProt Entrez-Gene Orthologous residues SYN1 (human): S9‑p, SYN1 iso2 (human): S9‑p, SYN1 (mouse): S9‑p, SYN1 iso1 (mouse): S9‑p, SYN1 iso3 (mouse): S9‑p, SYN1 (rat): S9‑p, SYN1 (cow): S9‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  neuron-'brain, cerebral cortex' Cellular systems studied:  primary cultured cells Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes deoxygenation, ischemia/reperfusion no change compared to control

S62-p - SYN1 (mouse) ▲

Modsite: stAAPVAsPAAPsPG SwissProt Entrez-Gene Orthologous residues SYN1 (human): S62‑p, SYN1 iso2 (human): S62‑p, SYN1 (mouse): S62‑p, SYN1 iso1 (mouse): S62‑p, SYN1 iso3 (mouse): S62‑p, SYN1 (rat): S62‑p, SYN1 (cow): S62‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  neuron-'brain, cerebral cortex' Cellular systems studied:  primary cultured cells Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes deoxygenation, ischemia/reperfusion no change compared to control

S551-p - SYN1 (mouse) ▲

Modsite: PAArPPAsPsPQrQA SwissProt Entrez-Gene Orthologous residues SYN1 (human): S551‑p, SYN1 iso2 (human): S551‑p, SYN1 (mouse): S551‑p, SYN1 iso1 (mouse): S551‑p, SYN1 iso3 (mouse): S551‑p, SYN1 (rat): S549‑p, SYN1 (cow): S551‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  neuron-'brain, cerebral cortex' Cellular systems studied:  primary cultured cells Species studied:  mouse Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKCG (human) co-immunoprecipitation, genetic knockout/knockin of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes deoxygenation, ischemia/reperfusion decrease Downstream Regulation Effect of modification (process):  cytoskeletal reorganization Comments:  OGD induces morphological damage of neurites in cortical neurons; protects against ischemic injury and cell death

S553-p - SYN1 (mouse) ▲

Modsite: ArPPAsPsPQrQAGA SwissProt Entrez-Gene Orthologous residues SYN1 (human): S553‑p, SYN1 iso2 (human): S553‑p, SYN1 (mouse): S553‑p, SYN1 iso1 (mouse): S553‑p, SYN1 iso3 (mouse): S553‑p, SYN1 (rat): S551‑p, SYN1 (cow): S553‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  neuron-'brain, cerebral cortex' Cellular systems studied:  primary cultured cells Species studied:  mouse Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKCG (human) co-immunoprecipitation, genetic knockout/knockin of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes deoxygenation, ischemia/reperfusion decrease Downstream Regulation Effect of modification (process):  cytoskeletal reorganization Comments:  OGD induces morphological damage of neurites in cortical neurons; protects against ischemic injury and cell death

S605-p - SYN1 (mouse) ▲

Modsite: AGPtRQAsQAGPGPr SwissProt Entrez-Gene Orthologous residues SYN1 (human): S605‑p, SYN1 iso2 (human): S605‑p, SYN1 (mouse): S605‑p, SYN1 iso1 (mouse): S605‑p, SYN1 iso3 (mouse): S577‑p, SYN1 (rat): S603‑p, SYN1 (cow): S605‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  neuron-'brain, cerebral cortex' Cellular systems studied:  primary cultured cells Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes deoxygenation, ischemia/reperfusion no change compared to control