Curated Information
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Home > Curated Information Page > PubMed Id: 17531442
Au WW, Henderson BR (2007) Identification of sequences that target BRCA1 to nuclear foci following alkylative DNA damage. Cell Signal 19, 1879-92 17531442
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S1143-p - BRCA1 (human)
Modsite: PMGSSHAsQVCSETP SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S1143‑p, BRCA1 iso6 (human): , BRCA1 iso7 (human): S1143‑p, BRCA1 (mouse): F1106‑p, BRCA1 (rat): F1107‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  S1143 and S1280 phosphorylation contributes to BRCA1 recruitment to MMTS-induced foci.

S1280-p - BRCA1 (human)
Modsite: QVILAkAsQEHHLsE SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S1280‑p, BRCA1 iso6 (human): , BRCA1 iso7 (human): S1280‑p, BRCA1 (mouse): S1241‑p, BRCA1 (rat): S1242‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  S1143 and S1280 phosphorylation contributes to BRCA1 recruitment to MMTS-induced foci.