Nencioni L, et al. (2009) Bcl-2 Expression and p38MAPK Activity in Cells Infected with Influenza A Virus: IMPACT ON VIRALLY INDUCED APOPTOSIS AND VIRAL REPLICATION. J Biol Chem 284, 16004-15 19336399

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T56-p - Bcl-2 (human) ▲

Modsite: FSSQPGHtPHPAASR SwissProt Entrez-Gene Orthologous residues Bcl‑2 (human): T56‑p, Bcl‑2 (mouse): N56‑p, Bcl‑2 (rat): N56‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  MDCK (epithelial), SH-SY5Y (neural crest) Cellular systems studied:  cell lines Species studied:  dog Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE P38A (human) co-immunoprecipitation, pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes virus infection increase influenza virus SB203580 virus infection inhibit treatment-induced increase Downstream Regulation Effect of modification (process):  apoptosis, altered Comments:  phosphorylation induced by viral infection

S87-p - Bcl-2 (human) ▲

Modsite: AAAGPALsPVPPVVH SwissProt Entrez-Gene Orthologous residues Bcl‑2 (human): S87‑p, Bcl‑2 (mouse): S84‑p, Bcl‑2 (rat): S84‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  MDCK (epithelial), SH-SY5Y (neural crest) Cellular systems studied:  cell lines Species studied:  dog Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE P38A (human) co-immunoprecipitation, pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes virus infection increase influenza virus SB203580 virus infection inhibit treatment-induced increase Downstream Regulation Effect of modification (process):  apoptosis, altered Comments:  phosphorylation induced by viral infection

T334-p - MAPKAPK2 (human) ▲

Modsite: QstKVPQtPLHtsRV SwissProt Entrez-Gene Orthologous residues MAPKAPK2 (human): T334‑p, MAPKAPK2 iso2 (human): T334‑p, MAPKAPK2 (mouse): T320‑p, MAPKAPK2 (rat): T320‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  MDCK (epithelial), SH-SY5Y (neural crest) Cellular systems studied:  cell lines Species studied:  dog Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes virus infection increase influenza virus SB203580 virus infection inhibit treatment-induced increase

T180-p - P38A (human) ▲

Modsite: RHtDDEMtGyVAtRW SwissProt Entrez-Gene Orthologous residues P38A (human): T180‑p, P38A iso2 (human): T180‑p, P38A (mouse): T180‑p, P38A iso3 (mouse): T180‑p, P38A (rat): T180‑p, P38A (salmonid): T181‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  MDCK (epithelial), SH-SY5Y (neural crest) Cellular systems studied:  cell lines Species studied:  dog Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes virus infection no change compared to control siRNA virus infection Bcl-2 (human) increase Downstream Regulation Effect of modification (function):  activity, induced Effect of modification (process):  apoptosis, altered

Y182-p - P38A (human) ▲

Modsite: tDDEMtGyVAtRWYR SwissProt Entrez-Gene Orthologous residues P38A (human): Y182‑p, P38A iso2 (human): Y182‑p, P38A (mouse): Y182‑p, P38A iso3 (mouse): Y182‑p, P38A (rat): Y182‑p, P38A (salmonid): Y183‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  MDCK (epithelial), SH-SY5Y (neural crest) Cellular systems studied:  cell lines Species studied:  dog Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes virus infection no change compared to control siRNA virus infection Bcl-2 (human) increase Downstream Regulation Effect of modification (function):  activity, induced Effect of modification (process):  apoptosis, altered