Curated Information
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Home > Curated Information Page > PubMed Id: 19303846
Mao Y, et al. (2009) Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 136, 1017-31 19303846
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T222-p - C/EBP-alpha (mouse)
Modsite: HLQPGHPtPPPtPVP SwissProt Entrez-Gene
Orthologous residues
C/EBP‑alpha (human): T226‑p, C/EBP‑alpha (mouse): T222‑p, C/EBP‑alpha (rat): T222‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 'neuron, hippocampal'-brain
Cellular systems studied:  primary cultured cells
Species studied:  mouse
Comments:  adult hippocampal progenitor cells (AHPs)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DISC1 (mouse) no change compared to control
siRNA DISC1 (mouse) no change compared to control

T226-p - C/EBP-alpha (mouse)
Modsite: GHPtPPPtPVPsPHA SwissProt Entrez-Gene
Orthologous residues
C/EBP‑alpha (human): T230‑p, C/EBP‑alpha (mouse): T226‑p, C/EBP‑alpha (rat): T226‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 'neuron, hippocampal'-brain
Cellular systems studied:  primary cultured cells
Species studied:  mouse
Comments:  adult hippocampal progenitor cells (AHPs)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DISC1 (mouse) no change compared to control
siRNA DISC1 (mouse) no change compared to control

S33-p - CTNNB1 (mouse)
Modsite: QQQsYLDsGIHsGAT SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): S33‑p, CTNNB1 (mouse): S33‑p, CTNNB1 (rat): S33‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 'neuron, hippocampal'-brain
Cellular systems studied:  primary cultured cells
Species studied:  mouse
Comments:  adult hippocampal progenitor cells (AHPs)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA DISC1 (mouse) increase
DISC1 (human) decrease

S37-p - CTNNB1 (mouse)
Modsite: YLDsGIHsGATtTAP SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): S37‑p, CTNNB1 (mouse): S37‑p, CTNNB1 (rat): S37‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 'neuron, hippocampal'-brain
Cellular systems studied:  primary cultured cells
Species studied:  mouse
Comments:  adult hippocampal progenitor cells (AHPs)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA DISC1 (mouse) increase
DISC1 (human) decrease

T41-p - CTNNB1 (mouse)
Modsite: GIHsGATtTAPsLSG SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): T41‑p, CTNNB1 (mouse): T41‑p, CTNNB1 (rat): T41‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 'neuron, hippocampal'-brain
Cellular systems studied:  primary cultured cells
Species studied:  mouse
Comments:  adult hippocampal progenitor cells (AHPs)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA DISC1 (mouse) increase
DISC1 (human) decrease

S9-p - GSK3B (mouse)
Modsite: SGRPRttsFAEsCKP SwissProt Entrez-Gene
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S9‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 'neuron, hippocampal'-brain
Cellular systems studied:  primary cultured cells
Species studied:  mouse
Comments:  adult hippocampal progenitor cells (AHPs)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DISC1 (mouse) no change compared to control
siRNA DISC1 (mouse) no change compared to control

Y216-p - GSK3B (mouse)
Modsite: RGEPNVsyICsRYYR SwissProt Entrez-Gene
Orthologous residues
GSK3B (human): Y216‑p, GSK3B iso2 (human): Y216‑p, GSK3B (mouse): Y216‑p, GSK3B (rat): Y216‑p, GSK3B (rabbit): Y216‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 'neuron, hippocampal'-brain
Cellular systems studied:  primary cultured cells
Species studied:  mouse
Comments:  adult hippocampal progenitor cells (AHPs)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA DISC1 (mouse) increase
DISC1 (human) decrease

S231-p - neurogenin 2 (mouse)
Modsite: SPYSCTLsPAsPGSD SwissProt Entrez-Gene
Orthologous residues
neurogenin 2 (human): S239‑p, neurogenin 2 (mouse): S231‑p, neurogenin 2 (rat): S231‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 'neuron, hippocampal'-brain
Cellular systems studied:  primary cultured cells
Species studied:  mouse
Comments:  adult hippocampal progenitor cells (AHPs)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DISC1 (mouse) no change compared to control
siRNA DISC1 (mouse) no change compared to control

S234-p - neurogenin 2 (mouse)
Modsite: SCTLsPAsPGSDVDy SwissProt Entrez-Gene
Orthologous residues
neurogenin 2 (human): S242‑p, neurogenin 2 (mouse): S234‑p, neurogenin 2 (rat): S234‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 'neuron, hippocampal'-brain
Cellular systems studied:  primary cultured cells
Species studied:  mouse
Comments:  adult hippocampal progenitor cells (AHPs)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DISC1 (mouse) no change compared to control
siRNA DISC1 (mouse) no change compared to control