Curated Information
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Home > Curated Information Page > PubMed Id: 19366211
Rybin VO, et al. (2009) Regulatory autophosphorylation sites on protein kinase C-delta at threonine-141 and threonine-295. Biochemistry 48, 4642-51 19366211
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T141-p - PKCD (human)
Modsite: EDEAkFPtMNRRGAI SwissProt Entrez-Gene
Orthologous residues
PKCD (human): T141‑p, PKCD iso2 (human): T141‑p, PKCD (mouse): T141‑p, PKCD iso2 (mouse): T141‑p, PKCD (rat): T141‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCD (human)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

T218-p - PKCD (human)
Modsite: TAANSRDtIFQkERF SwissProt Entrez-Gene
Orthologous residues
PKCD (human): T218‑p, PKCD iso2 (human): T218‑p, PKCD (mouse): T218‑p, PKCD iso2 (mouse): T218‑p, PKCD (rat): T218‑p

T295-p - PKCD (human)
Modsite: AEALNQVtQRAsRRs SwissProt Entrez-Gene
Orthologous residues
PKCD (human): T295‑p, PKCD iso2 (human): T295‑p, PKCD (mouse): T295‑p, PKCD iso2 (mouse): T295‑p, PKCD (rat): T295‑p
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

S302-p - PKCD (human)
Modsite: tQRAsRRsDsAssEP SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S302‑p, PKCD iso2 (human): S302‑p, PKCD (mouse): , PKCD iso2 (mouse): , PKCD (rat):

S304-p - PKCD (human)
Modsite: RAsRRsDsAssEPVG SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S304‑p, PKCD iso2 (human): S304‑p, PKCD (mouse): , PKCD iso2 (mouse): , PKCD (rat):

Y313-p - PKCD (human)
Modsite: ssEPVGIyQGFEKkT SwissProt Entrez-Gene
Orthologous residues
PKCD (human): Y313‑p, PKCD iso2 (human): Y313‑p, PKCD (mouse): Y311‑p, PKCD iso2 (mouse): Y311‑p, PKCD (rat): Y311‑p

Y334-p - PKCD (human)
Modsite: MQDNsGtyGkIWEGs SwissProt Entrez-Gene
Orthologous residues
PKCD (human): Y334‑p, PKCD iso2 (human): Y365‑p, PKCD (mouse): Y332‑p, PKCD iso2 (mouse): Y358‑p, PKCD (rat): Y332‑p

S503-p - PKCD (human)
Modsite: kENIFGEsRAstFCG SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S503‑p, PKCD iso2 (human): S534‑p, PKCD (mouse): G501‑p, PKCD iso2 (mouse): G527‑p, PKCD (rat): N501‑p

S645-p - PKCD (human)
Modsite: LNEkARLsysDKNLI SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S645‑p, PKCD iso2 (human): S676‑p, PKCD (mouse): S643‑p, PKCD iso2 (mouse): S669‑p, PKCD (rat): S643‑p

S23-p - TNNI3 (human)
Modsite: PAPIRRRssNyRAyA SwissProt Entrez-Gene
Orthologous residues
TNNI3 (human): S23‑p, TNNI3 (mouse): S23‑p, TNNI3 (rat): S23‑p, TNNI3 (rabbit): S22‑p, TNNI3 (dog): S23‑p, TNNI3 (cow): S24‑p

S24-p - TNNI3 (human)
Modsite: APIRRRssNyRAyAt SwissProt Entrez-Gene
Orthologous residues
TNNI3 (human): S24‑p, TNNI3 (mouse): S24‑p, TNNI3 (rat): S24‑p, TNNI3 (rabbit): S23‑p, TNNI3 (dog): S24‑p, TNNI3 (cow): S25‑p

T143-p - TNNI3 (human)
Modsite: RGKFKRPtLRRVrIs SwissProt Entrez-Gene
Orthologous residues
TNNI3 (human): T143‑p, TNNI3 (mouse): T144‑p, TNNI3 (rat): T144‑p, TNNI3 (rabbit): T143‑p, TNNI3 (dog): T144‑p, TNNI3 (cow): T145‑p