Curated Information
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Home > Curated Information Page > PubMed Id: 19282665
Di Costanzo A, et al. (2009) Homeodomain protein Dlx3 induces phosphorylation-dependent p63 degradation. Cell Cycle 8, 1185-95 19282665
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S477-p - p63 (human)
Modsite: NSMNKLPsVsQLINP SwissProt Entrez-Gene
Orthologous residues
p63 (human): S477‑p, p63 iso2 (human): S383‑p, p63 (mouse): S477‑p, p63 (rat): S477‑p
Downstream Regulation
Effect of modification (function):  protein degradation
Comments:  DLX3-mediated degradation

T491-p - p63 (human)
Modsite: PQQRNALtPTTIPDG SwissProt Entrez-Gene
Orthologous residues
p63 (human): T491‑p, p63 iso2 (human): T397‑p, p63 (mouse): T491‑p, p63 (rat): T491‑p
Downstream Regulation
Effect of modification (function):  protein degradation
Comments:  DLX3-mediated degradation

S338-p - RAF1 (human)
Modsite: RPRGQRDssyyWEIE SwissProt Entrez-Gene
Orthologous residues
RAF1 (human): S338‑p, RAF1 iso2 (human): S358‑p, RAF1 (mouse): S338‑p, RAF1 (rat): S338‑p, RAF1 (chicken): S338‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DLX3 (human) increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced