Curated Information
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Home > Curated Information Page > PubMed Id: 19339242
Prats C, et al. (2009) Dual regulation of muscle glycogen synthase during exercise by activation and compartmentalization. J Biol Chem 284, 15692-700 19339242
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S8-p - GYS1 (human)
Modsite: MPLNRtLsMssLPGL SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S8‑p, GYS1 iso2 (human): S8‑p, GYS1 (mouse): S8‑p, GYS1 (rat): S8‑p, GYS1 (rabbit): S8‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
exercise increase regular exercise
exercise no change compared to control after previous glycogen-depleting exercise
rest after exercise exercise no change compared to control
Downstream Regulation
Effect of modification (function):  enzymatic activity, inhibited

S11-p - GYS1 (human)
Modsite: NRtLsMssLPGLEDW SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S11‑p, GYS1 iso2 (human): S11‑p, GYS1 (mouse): S11‑p, GYS1 (rat): S11‑p, GYS1 (rabbit): S11‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
exercise increase regular exercise
exercise no change compared to control after previous glycogen-depleting exercise
rest after exercise exercise no change compared to control
Downstream Regulation
Effect of modification (function):  enzymatic activity, inhibited

S641-p - GYS1 (human)
Modsite: YRyPRPAsVPPsPsL SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S641‑p, GYS1 iso2 (human): S577‑p, GYS1 (mouse): S641‑p, GYS1 (rat): S641‑p, GYS1 (rabbit): S641‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
exercise decrease regular exercise
exercise decrease after previous glycogen-depleting exercise
rest after exercise exercise no effect upon treatment-induced decrease
Downstream Regulation
Effect of modification (function):  enzymatic activity, inhibited

S645-p - GYS1 (human)
Modsite: RPAsVPPsPsLsRHs SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S645‑p, GYS1 iso2 (human): S581‑p, GYS1 (mouse): S645‑p, GYS1 (rat): S645‑p, GYS1 (rabbit): S645‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
exercise decrease regular exercise
exercise decrease after previous glycogen-depleting exercise
rest after exercise exercise no effect upon treatment-induced decrease
Downstream Regulation
Effect of modification (function):  enzymatic activity, inhibited

S698-p - GYS1 (human)
Modsite: PEWPRRAsCtSSTSG SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S698‑p, GYS1 iso2 (human): S634‑p, GYS1 (mouse): S698‑p, GYS1 (rat): S698‑p, GYS1 (rabbit): S698‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
exercise no change compared to control regular exercise
exercise no change compared to control after previous glycogen-depleting exercise
rest after exercise exercise no change compared to control

S710-p - GYS1 (human)
Modsite: TSGSKRNsVDtAtss SwissProt Entrez-Gene
Orthologous residues
GYS1 (human): S710‑p, GYS1 iso2 (human): S646‑p, GYS1 (mouse): S711‑p, GYS1 (rat): S711‑p, GYS1 (rabbit): S711‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  tissue
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
exercise increase regular exercise
exercise increase after previous glycogen-depleting exercise
rest after exercise exercise inhibit treatment-induced increase