Curated Information
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Home > Curated Information Page > PubMed Id: 16126174
Zhang K, Faiola F, Martinez E (2005) Six lysine residues on c-Myc are direct substrates for acetylation by p300. Biochem Biophys Res Commun 336, 274-80 16126174
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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K143-ac - Myc (human)
Modsite: SGFSAAAkLVSEkLA SwissProt Entrez-Gene
Orthologous residues
Myc (human): K143‑ac, Myc iso2 (human): K158‑ac, Myc (mouse): K144‑ac, Myc (rat): K144‑ac
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ZBTB17 (human) Induces pull-down assay
Comments:  induces association with ZBTB17 on specific target promoters

K157-ac - Myc (human)
Modsite: AsYQAARkDSGsPNP SwissProt Entrez-Gene
Orthologous residues
Myc (human): K157‑ac, Myc iso2 (human): K172‑ac, Myc (mouse): K158‑ac, Myc (rat): K158‑ac
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ZBTB17 (human) Induces pull-down assay
Comments:  induces association with ZBTB17 on specific target promoters

K275-ac - Myc (human)
Modsite: EKRQAPGkRsEsGsP SwissProt Entrez-Gene
Orthologous residues
Myc (human): K275‑ac, Myc iso2 (human): K290‑ac, Myc (mouse): K275‑ac, Myc (rat): K275‑ac
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ZBTB17 (human) Induces pull-down assay
Comments:  induces association with ZBTB17 on specific target promoters

K317-ac - Myc (human)
Modsite: AAPPSTRkDYPAAkR SwissProt Entrez-Gene
Orthologous residues
Myc (human): K317‑ac, Myc iso2 (human): K332‑ac, Myc (mouse): K317‑ac, Myc (rat): K317‑ac
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ZBTB17 (human) Induces pull-down assay
Comments:  induces association with ZBTB17 on specific target promoters

K323-ac - Myc (human)
Modsite: RkDYPAAkRVkLDsV SwissProt Entrez-Gene
Orthologous residues
Myc (human): K323‑ac, Myc iso2 (human): K338‑ac, Myc (mouse): K323‑ac, Myc (rat): K323‑ac
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ZBTB17 (human) Induces pull-down assay
Comments:  induces association with ZBTB17 on specific target promoters

K371-ac - Myc (human)
Modsite: RQRRNELkRsFFALR SwissProt Entrez-Gene
Orthologous residues
Myc (human): K371‑ac, Myc iso2 (human): K386‑ac, Myc (mouse): K371‑ac, Myc (rat): K371‑ac
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Enzymes shown to modify site in vitro
Type Enzyme
ACETYLTRANSFERASE p300 (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ZBTB17 (human) Induces pull-down assay
Comments:  induces association with ZBTB17 on specific target promoters