Chen H, et al. (1999) Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell 98, 675-86 10490106

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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K616-ac - SRC-3 (human) ▲
Modsite: QRGPLESkGHkkLLQ SwissProt Entrez-Gene Orthologous residues SRC‑3 (human): K616‑ac, SRC‑3 iso2 (human): K616‑ac, SRC‑3 (mouse): K609‑ac, SRC‑3 (rat): K316‑ac Characterization Enzymes shown to modify site in vitro:  Type Enzyme ACETYLTRANSFERASE p300 (human)

K619-ac - SRC-3 (human) ▲

Modsite: PLESkGHkkLLQLLT SwissProt Entrez-Gene Orthologous residues SRC‑3 (human): K619‑ac, SRC‑3 iso2 (human): K619‑ac, SRC‑3 (mouse): K612‑ac, SRC‑3 (rat): K319‑ac Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  CV1 (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey Enzymes shown to modify site in vitro:  Type Enzyme ACETYLTRANSFERASE p300 (human) Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  transcription, inhibited Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays ER-alpha (human) Disrupts EMSA

K620-ac - SRC-3 (human) ▲

Modsite: LESkGHkkLLQLLTC SwissProt Entrez-Gene Orthologous residues SRC‑3 (human): K620‑ac, SRC‑3 iso2 (human): K620‑ac, SRC‑3 (mouse): K613‑ac, SRC‑3 (rat): K320‑ac Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  CV1 (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey Enzymes shown to modify site in vitro:  Type Enzyme ACETYLTRANSFERASE p300 (human) Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  transcription, inhibited Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays ER-alpha (human) Disrupts EMSA